Lateral diffusion of wild-type and mutant L(d) antigens in L cells

M. Edidin, M. Zuniga

Research output: Contribution to journalArticlepeer-review


We have compared the lateral diffusion of intact transmembrane proteins, wild-type H-2L(d) antigens, with that of mutants truncated in the cytoplasmic domain. Diffusion coefficients and mobile fractions were similar for all molecules examined, from wild-type L(d) antigens with 31 residues on the cytoplasmic side of the plasma membrane to mutants with only four residues in the cytoplasmic domain. This result limits ways in which the lateral diffusion of a major histocompatibility antigen a transmembrane protein, can be constrained by interactions with other molecules.

Original languageEnglish (US)
Pages (from-to)2333-2335
Number of pages3
JournalJournal of Cell Biology
Issue number6
StatePublished - 1984

ASJC Scopus subject areas

  • Cell Biology


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