Latent tri-lineage potential of adult hippocampal neural stem cells revealed by Nf1 inactivation

Gerald J. Sun, Yi Zhou, Shiori Ito, Michael A. Bonaguidi, Genevieve Stein-O'brien, Nicholas K. Kawasaki, Nikhil Modak, Yuan Zhu, Guo Li Ming, Hongjun Song

Research output: Contribution to journalArticle

Abstract

Endogenous neural stem cells (NSCs) in the adult hippocampus are considered to be bi-potent, as they only produce neurons and astrocytes in vivo. In mouse, we found that inactivation of neurofibromin 1 (Nf1), a gene mutated in neurofibromatosis type 1, unlocked a latent oligodendrocyte lineage potential to produce all three lineages from NSCs in vivo. Our results suggest an avenue for promoting stem cell plasticity by targeting barriers of latent lineage potential.

Original languageEnglish (US)
Pages (from-to)1722-1724
Number of pages3
JournalNature Neuroscience
Volume18
Issue number12
DOIs
StatePublished - Nov 25 2015

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Neurofibromin 1
Neural Stem Cells
Neurofibromatosis 1
Oligodendroglia
Astrocytes
Hippocampus
Stem Cells
Neurons
Genes

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Sun, G. J., Zhou, Y., Ito, S., Bonaguidi, M. A., Stein-O'brien, G., Kawasaki, N. K., ... Song, H. (2015). Latent tri-lineage potential of adult hippocampal neural stem cells revealed by Nf1 inactivation. Nature Neuroscience, 18(12), 1722-1724. https://doi.org/10.1038/nn.4159

Latent tri-lineage potential of adult hippocampal neural stem cells revealed by Nf1 inactivation. / Sun, Gerald J.; Zhou, Yi; Ito, Shiori; Bonaguidi, Michael A.; Stein-O'brien, Genevieve; Kawasaki, Nicholas K.; Modak, Nikhil; Zhu, Yuan; Ming, Guo Li; Song, Hongjun.

In: Nature Neuroscience, Vol. 18, No. 12, 25.11.2015, p. 1722-1724.

Research output: Contribution to journalArticle

Sun, GJ, Zhou, Y, Ito, S, Bonaguidi, MA, Stein-O'brien, G, Kawasaki, NK, Modak, N, Zhu, Y, Ming, GL & Song, H 2015, 'Latent tri-lineage potential of adult hippocampal neural stem cells revealed by Nf1 inactivation', Nature Neuroscience, vol. 18, no. 12, pp. 1722-1724. https://doi.org/10.1038/nn.4159
Sun, Gerald J. ; Zhou, Yi ; Ito, Shiori ; Bonaguidi, Michael A. ; Stein-O'brien, Genevieve ; Kawasaki, Nicholas K. ; Modak, Nikhil ; Zhu, Yuan ; Ming, Guo Li ; Song, Hongjun. / Latent tri-lineage potential of adult hippocampal neural stem cells revealed by Nf1 inactivation. In: Nature Neuroscience. 2015 ; Vol. 18, No. 12. pp. 1722-1724.
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