Latent tri-lineage potential of adult hippocampal neural stem cells revealed by Nf1 inactivation

Gerald J. Sun, Yi Zhou, Shiori Ito, Michael A. Bonaguidi, Genevieve Stein-O'brien, Nicholas K. Kawasaki, Nikhil Modak, Yuan Zhu, Guo Li Ming, Hongjun Song

Research output: Contribution to journalArticle

Abstract

Endogenous neural stem cells (NSCs) in the adult hippocampus are considered to be bi-potent, as they only produce neurons and astrocytes in vivo. In mouse, we found that inactivation of neurofibromin 1 (Nf1), a gene mutated in neurofibromatosis type 1, unlocked a latent oligodendrocyte lineage potential to produce all three lineages from NSCs in vivo. Our results suggest an avenue for promoting stem cell plasticity by targeting barriers of latent lineage potential.

Original languageEnglish (US)
Pages (from-to)1722-1724
Number of pages3
JournalNature Neuroscience
Volume18
Issue number12
DOIs
StatePublished - Nov 25 2015

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ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Sun, G. J., Zhou, Y., Ito, S., Bonaguidi, M. A., Stein-O'brien, G., Kawasaki, N. K., Modak, N., Zhu, Y., Ming, G. L., & Song, H. (2015). Latent tri-lineage potential of adult hippocampal neural stem cells revealed by Nf1 inactivation. Nature Neuroscience, 18(12), 1722-1724. https://doi.org/10.1038/nn.4159