Latent Mycobacterium tuberculosis - Persistence, patience, and winning by waiting

Y. C. Manabe; W. R. Bishai

doi:10.1038/82139

Latent Mycobacterium tuberculosis - Persistence, patience, and winning by waiting

Y. C. Manabe, W. R. Bishai

Research output: Contribution to journal › Review article › peer-review

227 Scopus citations

Abstract

Mycobacterium tuberculosis is a globally successful pathogen due to its ability to persist for long periods of time unrecognized by the human immune system. The panoply of genes that allows the organism to enter latency and then re-emerge later during endogenous reinfection are now being elucidated. Novel antimicrobials and vaccines will need to target these mycobacterial pathogenic mechanisms to suceed against tuberculosis.

Original language	English (US)
Pages (from-to)	1327-1329
Number of pages	3
Journal	Nature medicine
Volume	6
Issue number	12
DOIs	https://doi.org/10.1038/82139
State	Published - 2000

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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abstract = "Mycobacterium tuberculosis is a globally successful pathogen due to its ability to persist for long periods of time unrecognized by the human immune system. The panoply of genes that allows the organism to enter latency and then re-emerge later during endogenous reinfection are now being elucidated. Novel antimicrobials and vaccines will need to target these mycobacterial pathogenic mechanisms to suceed against tuberculosis.",

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AB - Mycobacterium tuberculosis is a globally successful pathogen due to its ability to persist for long periods of time unrecognized by the human immune system. The panoply of genes that allows the organism to enter latency and then re-emerge later during endogenous reinfection are now being elucidated. Novel antimicrobials and vaccines will need to target these mycobacterial pathogenic mechanisms to suceed against tuberculosis.

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Latent Mycobacterium tuberculosis - Persistence, patience, and winning by waiting

Abstract

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