Latent Class Analysis of Gilles de la Tourette Syndrome Using Comorbidities: Clinical and Genetic Implications

Marco Grados, Carol A. Mathews

Research output: Contribution to journalArticle

Abstract

Background: Although susceptibility loci exist for Gilles de la Tourette syndrome (GTS), no causative gene has been identified, perhaps in part because of phenotypic heterogeneity. This study used latent class analyses (LCA) to identify GTS subphenotypes and assess characteristics and heritability of the classes. Methods: The study included 952 individuals from 222 GTS families recruited for genetic studies. LCA identified a best-fit model for combinations of the diagnoses of GTS, obsessive-compulsive disorder (OCD), OC symptoms and behaviors (OCS/OCB), and attention-deficit/hyperactivity disorder (ADHD) in a random sample of one sibling from each family (n = 197), a replication sample randomly chosen from the remaining siblings (n = 203), and in the entire sample (all siblings and parents, N = 952). Heritabilities were assessed for all categoric diagnoses and LCA classes using a variance components approach. Results: In this large sample of GTS sib pairs and their parents, three GTS-affected groups were identified-GTS + OCS/OCB (Class III), GTS + OCD (Class IV), and GTS + OCD + ADHD (Class V)-in addition to a minimally affected class (I) and a small chronic tics + OCD class (II). A preponderance of males and younger age at onset was found in more comorbidly affected classes. Only the GTS + OCD + ADHD class was highly heritable. Conclusions: Our data suggest that GTS classes may represent distinct entities, with both shared and unique etiologies. In particular, GTS + OCD + ADHD may represent a separate, heritable phenotype that can be used to further inform genetic studies.

Original languageEnglish (US)
Pages (from-to)219-225
Number of pages7
JournalBiological Psychiatry
Volume64
Issue number3
DOIs
StatePublished - Aug 1 2008

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Tourette Syndrome
Obsessive-Compulsive Disorder
Comorbidity
Attention Deficit Disorder with Hyperactivity
Tics
Age of Onset
Phenotype
Genes

Keywords

  • Attention-deficit/hyperactivity disorder
  • genetics
  • obsessive-compulsive disorder
  • Tourette syndrome

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Latent Class Analysis of Gilles de la Tourette Syndrome Using Comorbidities : Clinical and Genetic Implications. / Grados, Marco; Mathews, Carol A.

In: Biological Psychiatry, Vol. 64, No. 3, 01.08.2008, p. 219-225.

Research output: Contribution to journalArticle

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