Late survival and symptoms after repair of tetralogy of Fallot

N. M. Katz, E. H. Blackstone, J. W. Kirklin, A. D. Pacifico, L. M. Bargeron

Research output: Contribution to journalArticle

Abstract

The long-term results of 414 patients who underwent repair of tetralogy of Fallot between 1967 and 1977 were studied and correlated with the results of others. There were nine late deaths (8-year actuarial survival 95.8%). Six of the deaths were directly related to the malformation or its treatment. Eight patients (2.4%) required reoperation. Ten patients (4.8%) had arrhythmic symptoms. Eight (3.1%) had congestive heart failure that required treatment. The risk factors associated with late events of all types, including death, were: older age at repair, a high mean ratio of peak systolic right-to-left ventricular pressures (P(LV/RV)) immediately after repair, and the presence of a Potts anastomosis. Neither a transannular patch nor a previous Blalock-Taussig or Waterson anastomosis was an incremental risk factor. Bacterial endocarditis was not observed. Three hundred seven patients underwent repair primarily or after a single Blalock-Taussig or Waterson shunt and had a P(RV/LV) of 0.85 or less after repair. Among these selected patients, the actuarial survival was 98.1%, which is still lower than that for the general population (p = 0.12), and freedom from events was 95.9%. Late after repair, P(RV/LV) was lower by 6 ± 28% (± SD) than P(RV/LV) immediately after repair (p = 0.03) in the 33 restudied patients with such data. The higher the P(RV/LV) immediately after repair, the greater the percent reduction.

Original languageEnglish (US)
Pages (from-to)403-410
Number of pages8
JournalCirculation
Volume65
Issue number2
StatePublished - 1982
Externally publishedYes

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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  • Cite this

    Katz, N. M., Blackstone, E. H., Kirklin, J. W., Pacifico, A. D., & Bargeron, L. M. (1982). Late survival and symptoms after repair of tetralogy of Fallot. Circulation, 65(2), 403-410.