Late results of the Ross procedure

Tirone E. David, Maral Ouzounian, Carolyn M. David, Myriam Lafreniere-Roula, Cedric Manlhiot

Research output: Contribution to journalArticle

Abstract

Objective: The study objective was to examine the long-term results of the Ross procedure in a cohort of patients followed prospectively for more than 2 decades. Methods: From 1990 to 2004, 212 consecutive patients with a median age (interquartile range) of 34 years (28-41) underwent the Ross procedure; 82% had congenital aortic valve disease. The technique of aortic root replacement was used in one half of the patients. Patients have been followed prospectively for a median (interquartile range) of 18.0 (14.6-21.2) years. Valve function was assessed by echocardiography. Results: Cumulative mortality at 20 years was 10.8% (95% confidence interval, 6.5-17.8). Thirty patients required Ross-related reoperations and 3 for coronary artery disease. The cumulative probability of Ross-related reoperations at 20 years was 16.8% (95% confidence interval, 11.3-24.5), on the pulmonary autograft was 11.5% (95% confidence interval, 7.2-18.0), and on the pulmonary homograft was 8.2% (4.6-14.7). The implantation technique was not associated with the cumulative incidence of reoperations on the pulmonary autograft. The development of moderate or severe aortic insufficiency and pulmonary homograft dysfunction increased with time. At 20 years, the probability of aortic insufficiency was 13% (95% confidence interval, 8.0-20.3) and of pulmonary homograft dysfunction was 19.7% (95% confidence interval, 13.9-27.2). Preoperative aortic insufficiency was associated with increased odds of postoperative aortic insufficiency. Conclusions: The long-term results of the Ross procedure are excellent regardless of the implantation technique, but there is a progressive deterioration of function of both semilunar valves.

Original languageEnglish (US)
Pages (from-to)201-208
Number of pages8
JournalJournal of Thoracic and Cardiovascular Surgery
Volume157
Issue number1
DOIs
StatePublished - Jan 1 2019
Externally publishedYes

Fingerprint

Confidence Intervals
Lung
Reoperation
Allografts
Autografts
Aortic Diseases
Aortic Valve
Echocardiography
Coronary Artery Disease
Mortality
Incidence

Keywords

  • aortic valve replacement
  • Ross procedure

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

David, T. E., Ouzounian, M., David, C. M., Lafreniere-Roula, M., & Manlhiot, C. (2019). Late results of the Ross procedure. Journal of Thoracic and Cardiovascular Surgery, 157(1), 201-208. https://doi.org/10.1016/j.jtcvs.2018.06.037

Late results of the Ross procedure. / David, Tirone E.; Ouzounian, Maral; David, Carolyn M.; Lafreniere-Roula, Myriam; Manlhiot, Cedric.

In: Journal of Thoracic and Cardiovascular Surgery, Vol. 157, No. 1, 01.01.2019, p. 201-208.

Research output: Contribution to journalArticle

David, TE, Ouzounian, M, David, CM, Lafreniere-Roula, M & Manlhiot, C 2019, 'Late results of the Ross procedure', Journal of Thoracic and Cardiovascular Surgery, vol. 157, no. 1, pp. 201-208. https://doi.org/10.1016/j.jtcvs.2018.06.037
David, Tirone E. ; Ouzounian, Maral ; David, Carolyn M. ; Lafreniere-Roula, Myriam ; Manlhiot, Cedric. / Late results of the Ross procedure. In: Journal of Thoracic and Cardiovascular Surgery. 2019 ; Vol. 157, No. 1. pp. 201-208.
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AB - Objective: The study objective was to examine the long-term results of the Ross procedure in a cohort of patients followed prospectively for more than 2 decades. Methods: From 1990 to 2004, 212 consecutive patients with a median age (interquartile range) of 34 years (28-41) underwent the Ross procedure; 82% had congenital aortic valve disease. The technique of aortic root replacement was used in one half of the patients. Patients have been followed prospectively for a median (interquartile range) of 18.0 (14.6-21.2) years. Valve function was assessed by echocardiography. Results: Cumulative mortality at 20 years was 10.8% (95% confidence interval, 6.5-17.8). Thirty patients required Ross-related reoperations and 3 for coronary artery disease. The cumulative probability of Ross-related reoperations at 20 years was 16.8% (95% confidence interval, 11.3-24.5), on the pulmonary autograft was 11.5% (95% confidence interval, 7.2-18.0), and on the pulmonary homograft was 8.2% (4.6-14.7). The implantation technique was not associated with the cumulative incidence of reoperations on the pulmonary autograft. The development of moderate or severe aortic insufficiency and pulmonary homograft dysfunction increased with time. At 20 years, the probability of aortic insufficiency was 13% (95% confidence interval, 8.0-20.3) and of pulmonary homograft dysfunction was 19.7% (95% confidence interval, 13.9-27.2). Preoperative aortic insufficiency was associated with increased odds of postoperative aortic insufficiency. Conclusions: The long-term results of the Ross procedure are excellent regardless of the implantation technique, but there is a progressive deterioration of function of both semilunar valves.

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