Three experiments on the treatment of advanced murine-tuberculosis by long-term, mainly intermittent chemotherapy are reported. The association ethionamide-streptomycin, which is highly efficient if given daily, produces mediocre results if administered intermittently after an initial daily stage of three months. The results of intermittent administration of isoniazid-streptomycin are highly dependent on the frequency of administration, dosage and the initial stage of daily treatment. The same weekly amount of drugs given in two doses during the week produces better results than given in only one. Administration of isoniazid-streptomycin during 9-10 months, even daily, does not produce lasting sterilization of severe murine tuberculosis; after withdrawal of treatment there is reappearance of viable bacilli in all the animals. Since the situation is in all likelihood not the same in man, the applicability of evidence acquired through the murine model for human tuberculosis is restricted to events occurring during the period of treatment and not afterwards.
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine