Late results of long-term, intermittent chemotherapy of advanced, murine tuberculosis: Limits of the murine model

F. Grumbach, G. Canetti, J. Grosset, M. Le Lirzin

Research output: Contribution to journalArticle

Abstract

Three experiments on the treatment of advanced murine-tuberculosis by long-term, mainly intermittent chemotherapy are reported. The association ethionamide-streptomycin, which is highly efficient if given daily, produces mediocre results if administered intermittently after an initial daily stage of three months. The results of intermittent administration of isoniazid-streptomycin are highly dependent on the frequency of administration, dosage and the initial stage of daily treatment. The same weekly amount of drugs given in two doses during the week produces better results than given in only one. Administration of isoniazid-streptomycin during 9-10 months, even daily, does not produce lasting sterilization of severe murine tuberculosis; after withdrawal of treatment there is reappearance of viable bacilli in all the animals. Since the situation is in all likelihood not the same in man, the applicability of evidence acquired through the murine model for human tuberculosis is restricted to events occurring during the period of treatment and not afterwards.

Original languageEnglish (US)
Pages (from-to)11-26
Number of pages16
JournalTubercle
Volume48
Issue number1
StatePublished - Mar 1967
Externally publishedYes

Fingerprint

Tuberculosis
Streptomycin
Drug Therapy
Isoniazid
Ethionamide
Therapeutics
Bacillus
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Grumbach, F., Canetti, G., Grosset, J., & Le Lirzin, M. (1967). Late results of long-term, intermittent chemotherapy of advanced, murine tuberculosis: Limits of the murine model. Tubercle, 48(1), 11-26.

Late results of long-term, intermittent chemotherapy of advanced, murine tuberculosis : Limits of the murine model. / Grumbach, F.; Canetti, G.; Grosset, J.; Le Lirzin, M.

In: Tubercle, Vol. 48, No. 1, 03.1967, p. 11-26.

Research output: Contribution to journalArticle

Grumbach, F, Canetti, G, Grosset, J & Le Lirzin, M 1967, 'Late results of long-term, intermittent chemotherapy of advanced, murine tuberculosis: Limits of the murine model', Tubercle, vol. 48, no. 1, pp. 11-26.
Grumbach, F. ; Canetti, G. ; Grosset, J. ; Le Lirzin, M. / Late results of long-term, intermittent chemotherapy of advanced, murine tuberculosis : Limits of the murine model. In: Tubercle. 1967 ; Vol. 48, No. 1. pp. 11-26.
@article{cbc8642ce586421897bcdf1b3a0bbe10,
title = "Late results of long-term, intermittent chemotherapy of advanced, murine tuberculosis: Limits of the murine model",
abstract = "Three experiments on the treatment of advanced murine-tuberculosis by long-term, mainly intermittent chemotherapy are reported. The association ethionamide-streptomycin, which is highly efficient if given daily, produces mediocre results if administered intermittently after an initial daily stage of three months. The results of intermittent administration of isoniazid-streptomycin are highly dependent on the frequency of administration, dosage and the initial stage of daily treatment. The same weekly amount of drugs given in two doses during the week produces better results than given in only one. Administration of isoniazid-streptomycin during 9-10 months, even daily, does not produce lasting sterilization of severe murine tuberculosis; after withdrawal of treatment there is reappearance of viable bacilli in all the animals. Since the situation is in all likelihood not the same in man, the applicability of evidence acquired through the murine model for human tuberculosis is restricted to events occurring during the period of treatment and not afterwards.",
author = "F. Grumbach and G. Canetti and J. Grosset and {Le Lirzin}, M.",
year = "1967",
month = "3",
language = "English (US)",
volume = "48",
pages = "11--26",
journal = "Tubercle",
issn = "0041-3879",
publisher = "Churchill Livingstone",
number = "1",

}

TY - JOUR

T1 - Late results of long-term, intermittent chemotherapy of advanced, murine tuberculosis

T2 - Limits of the murine model

AU - Grumbach, F.

AU - Canetti, G.

AU - Grosset, J.

AU - Le Lirzin, M.

PY - 1967/3

Y1 - 1967/3

N2 - Three experiments on the treatment of advanced murine-tuberculosis by long-term, mainly intermittent chemotherapy are reported. The association ethionamide-streptomycin, which is highly efficient if given daily, produces mediocre results if administered intermittently after an initial daily stage of three months. The results of intermittent administration of isoniazid-streptomycin are highly dependent on the frequency of administration, dosage and the initial stage of daily treatment. The same weekly amount of drugs given in two doses during the week produces better results than given in only one. Administration of isoniazid-streptomycin during 9-10 months, even daily, does not produce lasting sterilization of severe murine tuberculosis; after withdrawal of treatment there is reappearance of viable bacilli in all the animals. Since the situation is in all likelihood not the same in man, the applicability of evidence acquired through the murine model for human tuberculosis is restricted to events occurring during the period of treatment and not afterwards.

AB - Three experiments on the treatment of advanced murine-tuberculosis by long-term, mainly intermittent chemotherapy are reported. The association ethionamide-streptomycin, which is highly efficient if given daily, produces mediocre results if administered intermittently after an initial daily stage of three months. The results of intermittent administration of isoniazid-streptomycin are highly dependent on the frequency of administration, dosage and the initial stage of daily treatment. The same weekly amount of drugs given in two doses during the week produces better results than given in only one. Administration of isoniazid-streptomycin during 9-10 months, even daily, does not produce lasting sterilization of severe murine tuberculosis; after withdrawal of treatment there is reappearance of viable bacilli in all the animals. Since the situation is in all likelihood not the same in man, the applicability of evidence acquired through the murine model for human tuberculosis is restricted to events occurring during the period of treatment and not afterwards.

UR - http://www.scopus.com/inward/record.url?scp=0014061730&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0014061730&partnerID=8YFLogxK

M3 - Article

C2 - 6034625

AN - SCOPUS:0014061730

VL - 48

SP - 11

EP - 26

JO - Tubercle

JF - Tubercle

SN - 0041-3879

IS - 1

ER -