Late recurrent Candida endocarditis

P. G. Johnston, J. Lee, M. Domanski, F. Dressler, E. Tucker, M. Rothenberg, R. E. Cunnion, P. A. Pizzo, T. J. Walsh

Research output: Contribution to journalArticlepeer-review

Abstract

Late recurrent Candida endocarditis (LRCE) developed on a prosthetic mitral valve 22 months after treatment for primary native mitral valve endocarditis. The LRCE was difficult to diagnose; results of two dimensional echocardiography and repeated blood cultures were negative. Only transesophageal echocardiography revealed a vegetation and only lysis centrifugation blood cultures demonstrated candidemia. Postmortem examination revealed a large Candida vegetation on the prosthetic valve and Candida in the mitral valve ring. This case and a review of the literature indicate that Candida endocarditis treated with amphotericin B and prosthetic valve replacement may recur months after treatment, and that LRCE, which is difficult to diagnose and treat, may be best prevented by lifelong antifungal suppressive therapy.

Original languageEnglish (US)
Pages (from-to)1531-1533
Number of pages3
JournalCHEST
Volume99
Issue number6
DOIs
StatePublished - 1991

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

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