TY - JOUR
T1 - Late-life depressive symptoms
T2 - Prediction models of change
AU - García-Peña, Carmen
AU - Wagner, Fernando A.
AU - Sánchez-Garcí, Sergio
AU - Espinel-Bermúdez, Claudia
AU - Juárez-Cedillo, Teresa
AU - Pérez-Zepeda, Mario
AU - Arango-Lopera, Victoria
AU - Franco-Marina, Francisco
AU - Ramírez-Aldana, Ricardo
AU - Gallo, Joseph J.
N1 - Funding Information:
The sponsors were the National Council of Science, and Technology (Mexico) 2002-CO1-6868, the Mexican Institute of Social Security (IMSS 2002-382), and NIH-FIRCA R03 TW005888. Dr. Wagner was funded through grant DA019805-05 from NIDA, and P60-MD002217-01 from the NCMHHD. The funds were obtained through contests. CONACYT, and the other financing agencies had no role in the design methods, subjects, and analysis, other than providing funds for the research.
PY - 2013/9/25
Y1 - 2013/9/25
N2 - Background: Depression is a well-recognised problem in the elderly. The aim of this study was to determine the factors associated with predictors of change in depressive symptoms, both in subjects with and without baseline significant depressive symptoms. Methods: Longitudinal study of community-dwelling elderly people (> 60 years or older), baseline evaluations, and two additional evaluations were reported. Depressive symptoms were measured using a 30-item geriatric depression scale, and a score of 11 was used as cut-off point for significant depressive symptoms in order to stratify the analyses in two groups: with significant depressive symptoms and without significant depressive symptoms. Sociodemographic data, social support, anxiety, cognition, positive affect, control locus, activities of daily living, recent traumatic life events, physical activity, comorbidities, and quality of life were evaluated. Multi-level generalised estimating equation model was used to assess the impact on the trajectory of depressive symptoms. Results: A number of 7882 subjects were assessed, with 29.42%attrition. At baseline assessment, mean age was 70.96 years, 61.15%were women. Trajectories of depressive symptoms had a decreasing trend. Stronger associations in those with significant depressive symptoms, were social support (OR.971, p < .001), chronic pain (OR 2.277, p < .001) and higher locus of control (OR.581, p < .001). In contrast for those without baseline significant depressive symptoms anxiety and a higher locus of control were the strongest associations. Conclusions: New insights into late-life depression are provided, with special emphasis in differentiated factors influencing the trajectory when stratifying regarding basal status of significant depressive symptoms. Limitations: The study has not included clinical evaluations and nutritional assessments.
AB - Background: Depression is a well-recognised problem in the elderly. The aim of this study was to determine the factors associated with predictors of change in depressive symptoms, both in subjects with and without baseline significant depressive symptoms. Methods: Longitudinal study of community-dwelling elderly people (> 60 years or older), baseline evaluations, and two additional evaluations were reported. Depressive symptoms were measured using a 30-item geriatric depression scale, and a score of 11 was used as cut-off point for significant depressive symptoms in order to stratify the analyses in two groups: with significant depressive symptoms and without significant depressive symptoms. Sociodemographic data, social support, anxiety, cognition, positive affect, control locus, activities of daily living, recent traumatic life events, physical activity, comorbidities, and quality of life were evaluated. Multi-level generalised estimating equation model was used to assess the impact on the trajectory of depressive symptoms. Results: A number of 7882 subjects were assessed, with 29.42%attrition. At baseline assessment, mean age was 70.96 years, 61.15%were women. Trajectories of depressive symptoms had a decreasing trend. Stronger associations in those with significant depressive symptoms, were social support (OR.971, p < .001), chronic pain (OR 2.277, p < .001) and higher locus of control (OR.581, p < .001). In contrast for those without baseline significant depressive symptoms anxiety and a higher locus of control were the strongest associations. Conclusions: New insights into late-life depression are provided, with special emphasis in differentiated factors influencing the trajectory when stratifying regarding basal status of significant depressive symptoms. Limitations: The study has not included clinical evaluations and nutritional assessments.
KW - Depression trajectories
KW - Depressive symptoms
KW - Geriatric depression scale
KW - Geriatric syndromes
KW - Late-life depression
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U2 - 10.1016/j.jad.2013.05.007
DO - 10.1016/j.jad.2013.05.007
M3 - Article
C2 - 23731940
AN - SCOPUS:84888333229
SN - 0165-0327
VL - 150
SP - 886
EP - 894
JO - Journal of Affective Disorders
JF - Journal of Affective Disorders
IS - 3
ER -