Laser-Thermoablation zur Behandlung von pharmakoresistenten Epilepsien: Erfahrungen aus Philadelphia

Translated title of the contribution: Laser thermal ablation for treatment of drug-resistant epilepsy: Experiences from Philadelphia

Joon-Yi Kang, Michael R. Sperling

Research output: Contribution to journalArticle

Abstract

Laser interstitial thermal ablation is a new procedure used in the treatment of drug-resistant epilepsy. After the target structure reponsible for seizure initiation is identified, laser energy is applied using a stereotactically placed probe, which ablates structures adjacent to the probe tip. Small lesions responsible for seizures can be treated far less invasively than with open surgery, pain is reduced and hospitalization and recovery times are shorter. The use of this procedure to treat mesial temporal lobe epilepsy and hypothalamic hamartoma has so far shown promising results, with around half of the patients becoming seizure-free and with the smaller volume of ablated cortex leading to less neuropsychological deficits. Further research is needed to optimize targeting of structures for ablation and the selection of suitable candidates for surgery as well as for a better determination of efficacy rates and adverse effects.

Translated title of the contributionLaser thermal ablation for treatment of drug-resistant epilepsy: Experiences from Philadelphia
Original languageGerman
Pages (from-to)146-151
Number of pages6
JournalZeitschrift fur Epileptologie
Volume30
Issue number2
DOIs
StatePublished - May 1 2017

Keywords

  • Epileptic seizures
  • Hamartoma
  • Hippocampal sclerosis
  • Operative procedures
  • Partial temporal lobectomy

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

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