TY - JOUR
T1 - Laser spectroscopy for breath analysis
T2 - towards clinical implementation
AU - Henderson, Ben
AU - Khodabakhsh, Amir
AU - Metsälä, Markus
AU - Ventrillard, Irène
AU - Schmidt, Florian M.
AU - Romanini, Daniele
AU - Ritchie, Grant A.D.
AU - te Lintel Hekkert, Sacco
AU - Briot, Raphaël
AU - Risby, Terence
AU - Marczin, Nandor
AU - Harren, Frans J.M.
AU - Cristescu, Simona M.
N1 - Funding Information:
B.H. acknowledges support from the H2020-MSCA-ITN-2015, IMPACT project (nr. 674911). G. A. D. R. acknowledges support from the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC). The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health. F.M.S. acknowledges support from the Swedish Research Council (2013–6031) and the Kempe Foundations (SMK-1446). The authors thank the anonymous reviewers for their detailed and constructive comments. This article is part of the topical collection “Mid-infrared and THz Laser Sources and Applications” guest edited by Wei Ren, Paolo De Natale and Gerard Wysocki.
Publisher Copyright:
© 2018, The Author(s).
PY - 2018/8/1
Y1 - 2018/8/1
N2 - Detection and analysis of volatile compounds in exhaled breath represents an attractive tool for monitoring the metabolic status of a patient and disease diagnosis, since it is non-invasive and fast. Numerous studies have already demonstrated the benefit of breath analysis in clinical settings/applications and encouraged multidisciplinary research to reveal new insights regarding the origins, pathways, and pathophysiological roles of breath components. Many breath analysis methods are currently available to help explore these directions, ranging from mass spectrometry to laser-based spectroscopy and sensor arrays. This review presents an update of the current status of optical methods, using near and mid-infrared sources, for clinical breath gas analysis over the last decade and describes recent technological developments and their applications. The review includes: tunable diode laser absorption spectroscopy, cavity ring-down spectroscopy, integrated cavity output spectroscopy, cavity-enhanced absorption spectroscopy, photoacoustic spectroscopy, quartz-enhanced photoacoustic spectroscopy, and optical frequency comb spectroscopy. A SWOT analysis (strengths, weaknesses, opportunities, and threats) is presented that describes the laser-based techniques within the clinical framework of breath research and their appealing features for clinical use.
AB - Detection and analysis of volatile compounds in exhaled breath represents an attractive tool for monitoring the metabolic status of a patient and disease diagnosis, since it is non-invasive and fast. Numerous studies have already demonstrated the benefit of breath analysis in clinical settings/applications and encouraged multidisciplinary research to reveal new insights regarding the origins, pathways, and pathophysiological roles of breath components. Many breath analysis methods are currently available to help explore these directions, ranging from mass spectrometry to laser-based spectroscopy and sensor arrays. This review presents an update of the current status of optical methods, using near and mid-infrared sources, for clinical breath gas analysis over the last decade and describes recent technological developments and their applications. The review includes: tunable diode laser absorption spectroscopy, cavity ring-down spectroscopy, integrated cavity output spectroscopy, cavity-enhanced absorption spectroscopy, photoacoustic spectroscopy, quartz-enhanced photoacoustic spectroscopy, and optical frequency comb spectroscopy. A SWOT analysis (strengths, weaknesses, opportunities, and threats) is presented that describes the laser-based techniques within the clinical framework of breath research and their appealing features for clinical use.
UR - http://www.scopus.com/inward/record.url?scp=85050942138&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85050942138&partnerID=8YFLogxK
U2 - 10.1007/s00340-018-7030-x
DO - 10.1007/s00340-018-7030-x
M3 - Article
C2 - 30956412
AN - SCOPUS:85050942138
SN - 0946-2171
VL - 124
JO - Applied Physics B: Lasers and Optics
JF - Applied Physics B: Lasers and Optics
IS - 8
M1 - 161
ER -