TY - JOUR
T1 - Laser mass spectrometry
T2 - an overview of techniques, instruments and applications
AU - J. Cotter, Robert
N1 - Funding Information:
The author gratefully acknowledges the contributions of R. van Breemen, M. Colvin, M. Snow, J.-C. Tabet and J. Honovich in obtaining laser desorption spectra, and R. P. Lattimer, J. Hunt, N. Qureshi and K. Takayama for collaborative work. Research was supported in part by a grant (CHE 84-10506) from the National Science Foundation.
PY - 1987
Y1 - 1987
N2 - Lasers have been used to produce intact molecular ions and structurally informative fragment ions of otherwise intractable biomolecules for examination by mass spectrometry. While laser microprobes have been used for this purpose, this paper focusses on other instrumental configurations, which require less focussed laser beams and which record ions that are produced by mechanisms which can be described thermodynamically. The time-of-flight and Fourier-transform ion-cyclotron resonance mass spectrometers emerge as the most suitable for use with pulsed laser desorption. Classes of compounds which are amenable to the technique include industrial polymers and carbohydrates.
AB - Lasers have been used to produce intact molecular ions and structurally informative fragment ions of otherwise intractable biomolecules for examination by mass spectrometry. While laser microprobes have been used for this purpose, this paper focusses on other instrumental configurations, which require less focussed laser beams and which record ions that are produced by mechanisms which can be described thermodynamically. The time-of-flight and Fourier-transform ion-cyclotron resonance mass spectrometers emerge as the most suitable for use with pulsed laser desorption. Classes of compounds which are amenable to the technique include industrial polymers and carbohydrates.
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U2 - 10.1016/S0003-2670(00)85648-2
DO - 10.1016/S0003-2670(00)85648-2
M3 - Article
AN - SCOPUS:0003105698
SN - 0003-2670
VL - 195
SP - 45
EP - 59
JO - Analytica Chimica Acta
JF - Analytica Chimica Acta
IS - C
ER -