Laser light scattering study of the degradation of poly(sebacic anhydride) nanoparticles

Jie Fu; Chi Wu

doi:10.1002/1099-0488(20010315)39:6<703::AID-POLB1044>3.0.CO;2-B

Laser light scattering study of the degradation of poly(sebacic anhydride) nanoparticles

Research output: Contribution to journal › Article › peer-review

Abstract

Poly(sebacic anhydride) (PSA) is biocompatible and degradable in basic media. We micronized this water-insoluble polymer into stable polymeric nanoparticles via a microphase inversion. Such PSA nanoparticles degraded much faster than bulk PSA. The influence of the surfactant, temperature, and pH on the degradation of the PSA nanoparticles was investigated by a combination of static and dynamic laser light scattering. Under each condition, the degradation rate was nearly constant up to a 75% weight loss; that is, the degradation was close to zero-order. The degradation rate increased with the pH and temperature. Biomedical applications of such PSA nanoparticles are suggested.

Original language	English (US)
Pages (from-to)	703-708
Number of pages	6
Journal	Journal of Polymer Science, Part B: Polymer Physics
Volume	39
Issue number	6
DOIs	https://doi.org/10.1002/1099-0488(20010315)39:6<703::AID-POLB1044>3.0.CO;2-B
State	Published - Mar 15 2001
Externally published	Yes

ASJC Scopus subject areas

Condensed Matter Physics
Physical and Theoretical Chemistry
Polymers and Plastics
Materials Chemistry

Access to Document

10.1002/1099-0488(20010315)39:6<703::AID-POLB1044>3.0.CO;2-B

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abstract = "Poly(sebacic anhydride) (PSA) is biocompatible and degradable in basic media. We micronized this water-insoluble polymer into stable polymeric nanoparticles via a microphase inversion. Such PSA nanoparticles degraded much faster than bulk PSA. The influence of the surfactant, temperature, and pH on the degradation of the PSA nanoparticles was investigated by a combination of static and dynamic laser light scattering. Under each condition, the degradation rate was nearly constant up to a 75% weight loss; that is, the degradation was close to zero-order. The degradation rate increased with the pH and temperature. Biomedical applications of such PSA nanoparticles are suggested.",

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AB - Poly(sebacic anhydride) (PSA) is biocompatible and degradable in basic media. We micronized this water-insoluble polymer into stable polymeric nanoparticles via a microphase inversion. Such PSA nanoparticles degraded much faster than bulk PSA. The influence of the surfactant, temperature, and pH on the degradation of the PSA nanoparticles was investigated by a combination of static and dynamic laser light scattering. Under each condition, the degradation rate was nearly constant up to a 75% weight loss; that is, the degradation was close to zero-order. The degradation rate increased with the pH and temperature. Biomedical applications of such PSA nanoparticles are suggested.

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