Laser light scattering study of the degradation of poly(sebacic anhydride) nanoparticles

Jie Fu, Chi Wu

Research output: Contribution to journalArticlepeer-review

Abstract

Poly(sebacic anhydride) (PSA) is biocompatible and degradable in basic media. We micronized this water-insoluble polymer into stable polymeric nanoparticles via a microphase inversion. Such PSA nanoparticles degraded much faster than bulk PSA. The influence of the surfactant, temperature, and pH on the degradation of the PSA nanoparticles was investigated by a combination of static and dynamic laser light scattering. Under each condition, the degradation rate was nearly constant up to a 75% weight loss; that is, the degradation was close to zero-order. The degradation rate increased with the pH and temperature. Biomedical applications of such PSA nanoparticles are suggested.

Original languageEnglish (US)
Pages (from-to)703-708
Number of pages6
JournalJournal of Polymer Science, Part B: Polymer Physics
Volume39
Issue number6
DOIs
StatePublished - Mar 15 2001
Externally publishedYes

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Physical and Theoretical Chemistry
  • Polymers and Plastics
  • Materials Chemistry

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