TY - JOUR
T1 - Laser Flare Photometry
T2 - A Useful Tool for Monitoring Patients with Juvenile Idiopathic Arthritis-associated Uveitis
AU - Orès, Raphaëlle
AU - Terrada, Céline
AU - Errera, Marie Hélène
AU - Thorne, Jennifer E.
AU - Doukhan, Raphaël
AU - Cassoux, Nathalie
AU - Penaud, Benjamin
AU - LeHoang, Phuc
AU - Quartier, Pierre Marie
AU - Bodaghi, Bahram
N1 - Funding Information:
Dr. Thorne has funding from the Kids Uveitis Research and Education (KURE) fund at the Wilmer Eye Institute, without link with the present work. The authors thank Ms. Linda Northrup for English editing and Ms. Betty Sanadj for her assistance in files research. This work was presented as an oral poster presentation at the IOIS meeting in October 2017 in Lausanne, Switzerland, where it obtained the award for the best oral poster presentation.
Publisher Copyright:
© 2020 Taylor & Francis Group, LLC.
PY - 2022
Y1 - 2022
N2 - Purpose: We evaluated laser flare photometry (LFP) values in patients with juvenile idiopathic arthritis (JIA)-associated uveitis. Methods: Retrospective study. A decrease of the LFP value between baseline visit and 1 month after anti-inflammatory treatment intensification allowed us to define two groups of patients: group 1 (decreased LFP value ≥50%) and group 2 (<50%). We evaluated the prevalence of vision-threatening complications in both groups. Results: Fifty-four patients (87 eyes) were followed for 9.9 ± 5 years. Group 1 eyes (n = 54) had significantly fewer ocular complications than group 2 eyes (n = 33) at both 5 years visit (p = .03) and final visit (p = .047). At the final visit, group 2 eyes had significantly more band keratopathy, trabeculectomy, cataract surgery, glaucoma and papille edema. Group 1 eyes kept a better visual acuity (p < .0001). Conclusion: The decrease of LFP values ≥50% of the initial value 1 month after treatment intensification is a good early prognostic factor.
AB - Purpose: We evaluated laser flare photometry (LFP) values in patients with juvenile idiopathic arthritis (JIA)-associated uveitis. Methods: Retrospective study. A decrease of the LFP value between baseline visit and 1 month after anti-inflammatory treatment intensification allowed us to define two groups of patients: group 1 (decreased LFP value ≥50%) and group 2 (<50%). We evaluated the prevalence of vision-threatening complications in both groups. Results: Fifty-four patients (87 eyes) were followed for 9.9 ± 5 years. Group 1 eyes (n = 54) had significantly fewer ocular complications than group 2 eyes (n = 33) at both 5 years visit (p = .03) and final visit (p = .047). At the final visit, group 2 eyes had significantly more band keratopathy, trabeculectomy, cataract surgery, glaucoma and papille edema. Group 1 eyes kept a better visual acuity (p < .0001). Conclusion: The decrease of LFP values ≥50% of the initial value 1 month after treatment intensification is a good early prognostic factor.
KW - Uveitis
KW - juvenile idiopathic arthritis
KW - laser flare photometry
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U2 - 10.1080/09273948.2020.1792511
DO - 10.1080/09273948.2020.1792511
M3 - Article
C2 - 32835572
AN - SCOPUS:85089780711
VL - 30
SP - 118
EP - 128
JO - Ocular Immunology and Inflammation
JF - Ocular Immunology and Inflammation
SN - 0927-3948
IS - 1
ER -