TY - JOUR
T1 - Laser Desorption Time-of-Flight Mass Spectrometry of High Mass Molecules
AU - Tabet, Jean Claude
AU - Cotter, Robert J.
PY - 1984/8
Y1 - 1984/8
N2 - A laser desorption time-of-flight mass spectrometer Is described which uses a high-power, moderately focused, pulsed beam from a CO2 laser. Unlike the laser microprobe instruments, extended desorption follows the laser pulse, so that acceleration Is accomplished with a drawout pulse. The major Ionization process, cationization, Is consistent with a thermal model. Delaying the drawout pulse has some distinct advantages, particularly as molecules of higher molecular weight are studied. Delayed drawout pulsing samples Ions of lower energy spread and of varying degrees of fragmentation and can also be used to control metastable decompositions which occur In the accelerating region of the mass spectrometer. A number of peptides, glycosides, and other nonvolatile compounds provide examples of the analytical technique.
AB - A laser desorption time-of-flight mass spectrometer Is described which uses a high-power, moderately focused, pulsed beam from a CO2 laser. Unlike the laser microprobe instruments, extended desorption follows the laser pulse, so that acceleration Is accomplished with a drawout pulse. The major Ionization process, cationization, Is consistent with a thermal model. Delaying the drawout pulse has some distinct advantages, particularly as molecules of higher molecular weight are studied. Delayed drawout pulsing samples Ions of lower energy spread and of varying degrees of fragmentation and can also be used to control metastable decompositions which occur In the accelerating region of the mass spectrometer. A number of peptides, glycosides, and other nonvolatile compounds provide examples of the analytical technique.
UR - http://www.scopus.com/inward/record.url?scp=0021479242&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021479242&partnerID=8YFLogxK
U2 - 10.1021/ac00273a028
DO - 10.1021/ac00273a028
M3 - Article
AN - SCOPUS:0021479242
SN - 0003-2700
VL - 56
SP - 1662
EP - 1667
JO - Analytical Chemistry
JF - Analytical Chemistry
IS - 9
ER -