Laser Desorption Electron Impact: Application to a Study of the Mechanism of Conjugation of Glutathione and Cyclophosphamide

Zhimin Yuan, Catherine Fenselau, D. M. Dulik, William Martin, W. Bart Emary, R. B. Brundrett, O. M. Colvin, R. J. Cotter

Research output: Contribution to journalArticlepeer-review

Abstract

Toward the objective of producing ion radical species from involatile and thermally labile samples, we have combined laser desorption of neutral molecules with electron impact ionization on a time-of-flight mass analyzer with a delayed draw-out pulse. The analytical capabilities of this method are tested in the analysis of Isotope labels in the involatile product in a mechanistic study of both the chemical and the enzyme catalyzed reactions of cyclophosphamide with glutathione.

Original languageEnglish (US)
Pages (from-to)868-870
Number of pages3
JournalAnalytical chemistry
Volume62
Issue number8
DOIs
StatePublished - Apr 1 1990

ASJC Scopus subject areas

  • Analytical Chemistry

Fingerprint Dive into the research topics of 'Laser Desorption Electron Impact: Application to a Study of the Mechanism of Conjugation of Glutathione and Cyclophosphamide'. Together they form a unique fingerprint.

Cite this