Laser Desorption Electron Impact: Application to a Study of the Mechanism of Conjugation of Glutathione and Cyclophosphamide

Zhimin Yuan; Catherine Fenselau; D. M. Dulik; William Martin; W. Bart Emary; R. B. Brundrett; O. M. Colvin; R. J. Cotter

doi:10.1021/ac00207a020

Laser Desorption Electron Impact: Application to a Study of the Mechanism of Conjugation of Glutathione and Cyclophosphamide

Zhimin Yuan, Catherine Fenselau, D. M. Dulik, William Martin, W. Bart Emary, R. B. Brundrett, O. M. Colvin, R. J. Cotter

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Toward the objective of producing ion radical species from involatile and thermally labile samples, we have combined laser desorption of neutral molecules with electron impact ionization on a time-of-flight mass analyzer with a delayed draw-out pulse. The analytical capabilities of this method are tested in the analysis of Isotope labels in the involatile product in a mechanistic study of both the chemical and the enzyme catalyzed reactions of cyclophosphamide with glutathione.

Original language	English (US)
Pages (from-to)	868-870
Number of pages	3
Journal	Analytical Chemistry
Volume	62
Issue number	8
DOIs	https://doi.org/10.1021/ac00207a020
State	Published - Apr 1 1990
Externally published	Yes

ASJC Scopus subject areas

Analytical Chemistry

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10.1021/ac00207a020

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title = "Laser Desorption Electron Impact: Application to a Study of the Mechanism of Conjugation of Glutathione and Cyclophosphamide",

abstract = "Toward the objective of producing ion radical species from involatile and thermally labile samples, we have combined laser desorption of neutral molecules with electron impact ionization on a time-of-flight mass analyzer with a delayed draw-out pulse. The analytical capabilities of this method are tested in the analysis of Isotope labels in the involatile product in a mechanistic study of both the chemical and the enzyme catalyzed reactions of cyclophosphamide with glutathione.",

author = "Zhimin Yuan and Catherine Fenselau and Dulik, {D. M.} and William Martin and {Bart Emary}, W. and Brundrett, {R. B.} and Colvin, {O. M.} and Cotter, {R. J.}",

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T2 - Application to a Study of the Mechanism of Conjugation of Glutathione and Cyclophosphamide

AU - Yuan, Zhimin

AU - Fenselau, Catherine

AU - Dulik, D. M.

AU - Martin, William

AU - Bart Emary, W.

AU - Brundrett, R. B.

AU - Colvin, O. M.

AU - Cotter, R. J.

PY - 1990/4/1

Y1 - 1990/4/1

N2 - Toward the objective of producing ion radical species from involatile and thermally labile samples, we have combined laser desorption of neutral molecules with electron impact ionization on a time-of-flight mass analyzer with a delayed draw-out pulse. The analytical capabilities of this method are tested in the analysis of Isotope labels in the involatile product in a mechanistic study of both the chemical and the enzyme catalyzed reactions of cyclophosphamide with glutathione.

AB - Toward the objective of producing ion radical species from involatile and thermally labile samples, we have combined laser desorption of neutral molecules with electron impact ionization on a time-of-flight mass analyzer with a delayed draw-out pulse. The analytical capabilities of this method are tested in the analysis of Isotope labels in the involatile product in a mechanistic study of both the chemical and the enzyme catalyzed reactions of cyclophosphamide with glutathione.

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JO - Analytical Chemistry

JF - Analytical Chemistry

IS - 8

ER -

Laser Desorption Electron Impact: Application to a Study of the Mechanism of Conjugation of Glutathione and Cyclophosphamide

Abstract

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