TY - JOUR
T1 - Laryngeal penetration and aspiration during swallowing after the treatment of advanced oropharyngeal cancer
AU - Gillespie, M. Boyd
AU - Brodsky, Martin B.
AU - Day, Terry A.
AU - Sharma, Anand K.
AU - Lee, Fu Shing
AU - Martin-Harris, Bonnie
PY - 2005/7
Y1 - 2005/7
N2 - Objective: To determine whether laryngeal penetration and aspiration in oropharyngeal cancer survivors differ by treatment group. Design: Cross-sectional study of patients with stage III or IV oropharyngeal squamous cell carcinoma who were at least 12 months removed from combined modality therapy and clinically free of disease. Subjects: Potential subjects were stratified by tumor site and tumor T stage to achieve a similar comparison between chemoradiotherapy (n = 10) and surgery/radiotherapy (n = 11) groups. Validated instruments used to evaluate swallowing included the Penetration-Aspiration Scale and the M. D. Anderson Dysphagia Inventory. Results: Patients with oropharyngeal cancer treated with chemoradiotherapy demonstrated greater airway protection according to Penetration-Aspiration Scale scores than those treated with surgery and radiotherapy on 5-mL (P = .02), 10-mL (P = .04), and 20-mL (P = .04) liquid barium swallows. Also, the oropharyngeal chemoradiotherapy group had better self-perceived swallowing ability than the surgery-radiotherapy group on the basis of the M. D. Anderson Dysphagia Inventory (P = .02). Conclusion: The present study suggests that patients with oropharyngeal cancer who successfully complete chemoradiotherapy protocols without surgical salvage retain greater airway protection during swallowing and bet ter swallowing-related quality of life than patients treated with primary surgery and radiotherapy.
AB - Objective: To determine whether laryngeal penetration and aspiration in oropharyngeal cancer survivors differ by treatment group. Design: Cross-sectional study of patients with stage III or IV oropharyngeal squamous cell carcinoma who were at least 12 months removed from combined modality therapy and clinically free of disease. Subjects: Potential subjects were stratified by tumor site and tumor T stage to achieve a similar comparison between chemoradiotherapy (n = 10) and surgery/radiotherapy (n = 11) groups. Validated instruments used to evaluate swallowing included the Penetration-Aspiration Scale and the M. D. Anderson Dysphagia Inventory. Results: Patients with oropharyngeal cancer treated with chemoradiotherapy demonstrated greater airway protection according to Penetration-Aspiration Scale scores than those treated with surgery and radiotherapy on 5-mL (P = .02), 10-mL (P = .04), and 20-mL (P = .04) liquid barium swallows. Also, the oropharyngeal chemoradiotherapy group had better self-perceived swallowing ability than the surgery-radiotherapy group on the basis of the M. D. Anderson Dysphagia Inventory (P = .02). Conclusion: The present study suggests that patients with oropharyngeal cancer who successfully complete chemoradiotherapy protocols without surgical salvage retain greater airway protection during swallowing and bet ter swallowing-related quality of life than patients treated with primary surgery and radiotherapy.
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U2 - 10.1001/archotol.131.7.615
DO - 10.1001/archotol.131.7.615
M3 - Article
C2 - 16027285
AN - SCOPUS:23044445149
SN - 0886-4470
VL - 131
SP - 615
EP - 619
JO - Archives of Otolaryngology--Head and Neck Surgery
JF - Archives of Otolaryngology--Head and Neck Surgery
IS - 7
ER -