Laryngeal and vocal evaluation in untreated growth hormone deficient adults

Valéria M.P. Barreto, Jeferson S. D'Ávila, Neuza J. Sales, Maria Inês R. Gonçalves, Juliane Dantas Seabra, Roberto Salvatori, Manuel H. Aguiar-Oliveira

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Objective: To evaluate the consequences of lifetime, severe and untreated isolated growth hormone deficiency (IGHD) on vocal and laryngeal function. Study Design: Cross-sectional. Subjects and Methods: A total of 23 IGHD adult subjects and 22 controls were administered a questionnaire about vocal complaints and harmful voice habits, and underwent videolaryngostroboscopic examination, voice evaluation by perceptual-auditory analysis with GRBAS scale including grade of dysphonia, roughness, breathiness, asthenia and strain items, objective voice evaluation by maximum phonation time (MPT), and acoustic analysis. Results: There was no difference in vocal complaints between IGHD subjects and controls. Vocal abuse and smoking were more frequent in IGHD subjects. IGHD subjects presented higher values for roughness, breathiness, and strain. Laryngopharyngeal reflux (LPR) signs and laryngeal constriction were more frequent in IGHD individuals. MPT was similar in the two groups. Fundamental frequency was higher in IGHD females and males. Harmonic to noise ratio was higher in IGHD in both genders and shimmer was lower in IGHD females. Conclusions: IGHD subjects have higher prevalence of signs of LPR and laryngeal constriction, with high pitch in both genders, which suggests a prominent role of IGHD on these parameters.

Original languageEnglish (US)
Pages (from-to)37-42
Number of pages6
JournalOtolaryngology - Head and Neck Surgery
Issue number1
StatePublished - Jan 2009

ASJC Scopus subject areas

  • Surgery
  • Otorhinolaryngology


Dive into the research topics of 'Laryngeal and vocal evaluation in untreated growth hormone deficient adults'. Together they form a unique fingerprint.

Cite this