Larvicidal, antimycobacterial and antifungal compounds from the bark of the peruvian plant Swartzia polyphylla DC

Rosario Rojas, Betty Bustamante, Palmira Ventosilla, Irma Fernádez, Luz Caviedes, Robert Henry Gilman, Olga Lock, Gerald Bruce Hammond

Research output: Contribution to journalArticlepeer-review

Abstract

The 95% ethanol extract of the bark of Swartzia polyphylla DC (Fabaceae) possesses important larvicidal, antimycobacterial and antifungal activity in vitro. Bioassay-guided studies performed on the crude ethanol extract afforded T-cadinol as the larvicidal and anti-Mycobacterium tuberculosis principle, while the antifungal activity of the extract is due to the presence of the flavonoids biochanin A and dihydrobiochanin A.

Original languageEnglish (US)
Pages (from-to)278-279
Number of pages2
JournalChemical and Pharmaceutical Bulletin
Volume54
Issue number2
DOIs
StatePublished - Feb 1 2006

Keywords

  • Antifungal
  • Antimycobacterial
  • Biochanin A
  • Dihydrobiochanin A
  • Larvicidal
  • Swartzia polyphylla

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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