Large-scale surveillance of Plasmodium falciparum crt(K76T) in Northern Ghana

Stephan Ehrhardt, Teunis A. Eggelte, Sarah Kaiser, Lydia Adjei, Gerd D. Burchard, Sylvester D. Anemana, Ulrich Bienzle, Frank P. Mockenhaupt

Research output: Contribution to journalArticle

Abstract

Surveillance of Plasmodium falciparum crt(K76T) [Pfcrt(K76T)], a resistance marker of chloroquine and, limitedly, amodiaquine, in >4,000 children in northern Ghana revealed a prevalence of 79%. Pfcrt(K76T) was heterogeneously distributed and associated with chloroquine use, low parasitemia, and the dry season. Widespread chloroquine resistance challenges the regional life span of amodiaquine as a partner drug in artemisinin combination therapy.

Original languageEnglish (US)
Pages (from-to)3407-3409
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume51
Issue number9
DOIs
StatePublished - Sep 2007
Externally publishedYes

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Ghana
Chloroquine
Plasmodium falciparum
Amodiaquine
Parasitemia
Pharmaceutical Preparations
Therapeutics

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Ehrhardt, S., Eggelte, T. A., Kaiser, S., Adjei, L., Burchard, G. D., Anemana, S. D., ... Mockenhaupt, F. P. (2007). Large-scale surveillance of Plasmodium falciparum crt(K76T) in Northern Ghana. Antimicrobial Agents and Chemotherapy, 51(9), 3407-3409. https://doi.org/10.1128/AAC.00179-07

Large-scale surveillance of Plasmodium falciparum crt(K76T) in Northern Ghana. / Ehrhardt, Stephan; Eggelte, Teunis A.; Kaiser, Sarah; Adjei, Lydia; Burchard, Gerd D.; Anemana, Sylvester D.; Bienzle, Ulrich; Mockenhaupt, Frank P.

In: Antimicrobial Agents and Chemotherapy, Vol. 51, No. 9, 09.2007, p. 3407-3409.

Research output: Contribution to journalArticle

Ehrhardt, S, Eggelte, TA, Kaiser, S, Adjei, L, Burchard, GD, Anemana, SD, Bienzle, U & Mockenhaupt, FP 2007, 'Large-scale surveillance of Plasmodium falciparum crt(K76T) in Northern Ghana', Antimicrobial Agents and Chemotherapy, vol. 51, no. 9, pp. 3407-3409. https://doi.org/10.1128/AAC.00179-07
Ehrhardt, Stephan ; Eggelte, Teunis A. ; Kaiser, Sarah ; Adjei, Lydia ; Burchard, Gerd D. ; Anemana, Sylvester D. ; Bienzle, Ulrich ; Mockenhaupt, Frank P. / Large-scale surveillance of Plasmodium falciparum crt(K76T) in Northern Ghana. In: Antimicrobial Agents and Chemotherapy. 2007 ; Vol. 51, No. 9. pp. 3407-3409.
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