TY - JOUR
T1 - Large-scale surveillance of Plasmodium falciparum crt(K76T) in Northern Ghana
AU - Ehrhardt, Stephan
AU - Eggelte, Teunis A.
AU - Kaiser, Sarah
AU - Adjei, Lydia
AU - Burchard, Gerd D.
AU - Anemana, Sylvester D.
AU - Bienzle, Ulrich
AU - Mockenhaupt, Frank P.
PY - 2007/9
Y1 - 2007/9
N2 - Surveillance of Plasmodium falciparum crt(K76T) [Pfcrt(K76T)], a resistance marker of chloroquine and, limitedly, amodiaquine, in >4,000 children in northern Ghana revealed a prevalence of 79%. Pfcrt(K76T) was heterogeneously distributed and associated with chloroquine use, low parasitemia, and the dry season. Widespread chloroquine resistance challenges the regional life span of amodiaquine as a partner drug in artemisinin combination therapy.
AB - Surveillance of Plasmodium falciparum crt(K76T) [Pfcrt(K76T)], a resistance marker of chloroquine and, limitedly, amodiaquine, in >4,000 children in northern Ghana revealed a prevalence of 79%. Pfcrt(K76T) was heterogeneously distributed and associated with chloroquine use, low parasitemia, and the dry season. Widespread chloroquine resistance challenges the regional life span of amodiaquine as a partner drug in artemisinin combination therapy.
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U2 - 10.1128/AAC.00179-07
DO - 10.1128/AAC.00179-07
M3 - Article
C2 - 17562799
AN - SCOPUS:35948986291
SN - 0066-4804
VL - 51
SP - 3407
EP - 3409
JO - Antimicrobial agents and chemotherapy
JF - Antimicrobial agents and chemotherapy
IS - 9
ER -