Large-scale surveillance of Plasmodium falciparum crt(K76T) in Northern Ghana

Stephan Ehrhardt, Teunis A. Eggelte, Sarah Kaiser, Lydia Adjei, Gerd D. Burchard, Sylvester D. Anemana, Ulrich Bienzle, Frank P. Mockenhaupt

Research output: Contribution to journalArticlepeer-review

Abstract

Surveillance of Plasmodium falciparum crt(K76T) [Pfcrt(K76T)], a resistance marker of chloroquine and, limitedly, amodiaquine, in >4,000 children in northern Ghana revealed a prevalence of 79%. Pfcrt(K76T) was heterogeneously distributed and associated with chloroquine use, low parasitemia, and the dry season. Widespread chloroquine resistance challenges the regional life span of amodiaquine as a partner drug in artemisinin combination therapy.

Original languageEnglish (US)
Pages (from-to)3407-3409
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume51
Issue number9
DOIs
StatePublished - Sep 2007
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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