TY - JOUR
T1 - Large-scale recording of astrocyte activity
AU - Nimmerjahn, Axel
AU - Bergles, Dwight E.
N1 - Publisher Copyright:
© 2015 Elsevier Ltd.
PY - 2015/6/1
Y1 - 2015/6/1
N2 - Astrocytes are highly ramified glial cells found throughout the central nervous system (CNS). They express a variety of neurotransmitter receptors that can induce widespread chemical excitation, placing these cells in an optimal position to exert global effects on brain physiology. However, the activity patterns of only a small fraction of astrocytes have been examined and techniques to manipulate their behavior are limited. As a result, little is known about how astrocytes modulate CNS function on synaptic, microcircuit, or systems levels. Here, we review current and emerging approaches for visualizing and manipulating astrocyte activity in vivo. Deciphering how astrocyte network activity is controlled in different physiological and pathological contexts is crucial for defining their roles in the healthy and diseased CNS.
AB - Astrocytes are highly ramified glial cells found throughout the central nervous system (CNS). They express a variety of neurotransmitter receptors that can induce widespread chemical excitation, placing these cells in an optimal position to exert global effects on brain physiology. However, the activity patterns of only a small fraction of astrocytes have been examined and techniques to manipulate their behavior are limited. As a result, little is known about how astrocytes modulate CNS function on synaptic, microcircuit, or systems levels. Here, we review current and emerging approaches for visualizing and manipulating astrocyte activity in vivo. Deciphering how astrocyte network activity is controlled in different physiological and pathological contexts is crucial for defining their roles in the healthy and diseased CNS.
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U2 - 10.1016/j.conb.2015.01.015
DO - 10.1016/j.conb.2015.01.015
M3 - Review article
C2 - 25665733
AN - SCOPUS:84922342690
SN - 0959-4388
VL - 32
SP - 95
EP - 106
JO - Current Opinion in Neurobiology
JF - Current Opinion in Neurobiology
ER -