Large-scale clinical validation of a lateral flow immunoassay for detection of cryptococcal antigen in serum and cerebrospinal fluid specimens

Nuntra Suwantarat, Justin B. Dalton, Richard Lee, Rachel Green, Warda Memon, Karen C. Carroll, Stefan Riedel, Sean X. Zhang

Research output: Contribution to journalArticlepeer-review

Abstract

We compared a lateral flow immunoassay (LFA) to a currently used enzyme immunoassay for detection of cryptococcal antigen in 396 sera and 651 cerebrospinal fluid specimens. We found 97% concordance between the 2 assays. The LFA detected an additional 22 positives. Overall, the LFA had sensitivity of 100% and specificity of 99.6% for the diagnosis of cryptococcosis. The LFA is rapid, accurate, and easy to perform, and it is suitable for routine patient care testing.

Original languageEnglish (US)
Pages (from-to)54-56
Number of pages3
JournalDiagnostic Microbiology and Infectious Disease
Volume82
Issue number1
DOIs
StatePublished - May 1 2015

Keywords

  • Antigen
  • Cerebrospinal fluid
  • Cryptococcus
  • Lateral flow immunoassay
  • Serum

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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