Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus

Timothy L. Mosbruger, Priya Duggal, James J. Goedert, Gregory D Kirk, W. Keith Hoots, Leslie H. Tobler, Michael Busch, Marion G. Peters, Hugo R. Rosen, David L Thomas, Chloe L Thio

Research output: Contribution to journalArticle

Abstract

Human genetic variation is a determinant of recovery from acute hepatitis C virus (HCV) infection; however, to date, single-nucleotide polymorphisms (SNPs) in only a limited number of genes have been studied with respect to HCV clearance. We determined whether SNPs in 112 selected immune response genes are important for HCV clearance, by genotyping 1536 SNPs in a cohort of 343 persons with natural HCV clearance and 547 persons with HCV persistence. PLINK (version 1.05) and Haploview (version 4.1) software packages were used to perform association, permutation, and haplotype analyses stratified by African American and European American race. Of the 1536 SNPs tested, 1426 (92.8%) were successfully genotyped. In African Americans, we identified 18 SNPs located in 11 gene regions that were associated with HCV infection outcome (empirical P value, <.01). In European Americans, there were 20 SNPs located in 8 gene regions associated with HCV infection outcome. Four of the gene regions studied (TNFSF18, TANK, HAVCR1, and IL18BP) contained SNPs for which the empirical P value was

Original languageEnglish (US)
Pages (from-to)1371-1380
Number of pages10
JournalJournal of Infectious Diseases
Volume201
Issue number9
DOIs
StatePublished - May 1 2010

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Genetic Association Studies
Hepacivirus
Single Nucleotide Polymorphism
Virus Diseases
Genes
African Americans
Medical Genetics
Haplotypes
Software

ASJC Scopus subject areas

  • Infectious Diseases
  • Immunology and Allergy
  • Medicine(all)

Cite this

Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. / Mosbruger, Timothy L.; Duggal, Priya; Goedert, James J.; Kirk, Gregory D; Hoots, W. Keith; Tobler, Leslie H.; Busch, Michael; Peters, Marion G.; Rosen, Hugo R.; Thomas, David L; Thio, Chloe L.

In: Journal of Infectious Diseases, Vol. 201, No. 9, 01.05.2010, p. 1371-1380.

Research output: Contribution to journalArticle

Mosbruger, TL, Duggal, P, Goedert, JJ, Kirk, GD, Hoots, WK, Tobler, LH, Busch, M, Peters, MG, Rosen, HR, Thomas, DL & Thio, CL 2010, 'Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus', Journal of Infectious Diseases, vol. 201, no. 9, pp. 1371-1380. https://doi.org/10.1086/651606
Mosbruger, Timothy L. ; Duggal, Priya ; Goedert, James J. ; Kirk, Gregory D ; Hoots, W. Keith ; Tobler, Leslie H. ; Busch, Michael ; Peters, Marion G. ; Rosen, Hugo R. ; Thomas, David L ; Thio, Chloe L. / Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. In: Journal of Infectious Diseases. 2010 ; Vol. 201, No. 9. pp. 1371-1380.
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