Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease

Heribert Schunkert, Inke R. König, Sekar Kathiresan, Muredach P. Reilly, Themistocles L. Assimes, Hilma Holm, Michael Preuss, Alexandre F R Stewart, Maja Barbalic, Christian Gieger, Devin Absher, Zouhair Aherrahrou, Hooman Allayee, David Altshuler, Sonia S. Anand, Karl Andersen, Jeffrey L. Anderson, Diego Ardissino, Stephen G. Ball, Anthony J. Balmforth & 147 others Timothy A. Barnes, Diane M Becker, Lewis Becker, Klaus Berger, Joshua C. Bis, S. Matthijs Boekholdt, Eric Boerwinkle, Peter S. Braund, Morris J. Brown, Mary Susan Burnett, Ian Buysschaert, John F. Carlquist, Li Chen, Sven Cichon, Veryan Codd, Robert W. Davies, George Dedoussis, Abbas Dehghan, Serkalem Demissie, Joseph M. Devaney, Patrick Diemert, Ron Do, Angela Doering, Sandra Eifert, Nour Eddine El Mokhtari, Stephen G. Ellis, Roberto Elosua, James C. Engert, Stephen E. Epstein, Ulf De Faire, Marcus Fischer, Aaron R. Folsom, Jennifer Freyer, Bruna Gigante, Domenico Girelli, Solveig Gretarsdottir, Vilmundur Gudnason, Jeffrey R. Gulcher, Eran Halperin, Naomi Hammond, Stanley L. Hazen, Albert Hofman, Benjamin D. Horne, Thomas Illig, Carlos Iribarren, Gregory T. Jones, J. Wouter Jukema, Michael A. Kaiser, Lee M. Kaplan, John J P Kastelein, Kay Tee Khaw, Joshua W. Knowles, Genovefa Kolovou, Augustine Kong, Reijo Laaksonen, Diether Lambrechts, Karin Leander, Guillaume Lettre, Mingyao Li, Wolfgang Lieb, Christina Loley, Andrew J. Lotery, Pier M. Mannucci, Seraya Maouche, Nicola Martinelli, Pascal P. McKeown, Christa Meisinger, Thomas Meitinger, Olle Melander, Pier Angelica Merlini, Vincent Mooser, Thomas Morgan, Thomas W. Mühleisen, Joseph B. Muhlestein, Thomas Münzel, Kiran Musunuru, Janja Nahrstaedt, Christopher P. Nelson, Markus M. Nöthen, Oliviero Olivieri, Riyaz S. Patel, Chris C. Patterson, Annette Peters, Flora Peyvandi, Liming Qu, Arshed A. Quyyumi, Daniel J. Rader, Loukianos S. Rallidis, Catherine Rice, Frits R. Rosendaal, Diana Rubin, Veikko Salomaa, M. Lourdes Sampietro, Manj S. Sandhu, Eric Schadt, Arne Scḧsignfer, Arne Schillert, Stefan Schreiber, Jürgen Schrezenmeir, Stephen M. Schwartz, David S. Siscovick, Mohan Sivananthan, Suthesh Sivapalaratnam, Albert Smith, Tamara B. Smith, Jaapjan D. Snoep, Nicole Soranzo, John A. Spertus, Klaus Stark, Kathy Stirrups, Monika Stoll, W. H Wilson Tang, Stephanie Tennstedt, Gudmundur Thorgeirsson, Gudmar Thorleifsson, MacIej Tomaszewski, Andre G. Uitterlinden, Andre M. Van Rij, Benjamin F. Voight, Nick J. Wareham, George A. Wells, H. Erich Wichmann, Philipp S. Wild, Christina Willenborg, Jaqueline C M Witteman, Benjamin J. Wright, Shu Ye, Tanja Zeller, Andreas Ziegler, Francois Cambien, Alison H. Goodall, L. Adrienne Cupples, Thomas Quertermous, Winfried Mäsignrz, Christian Hengstenberg, Stefan Blankenberg, Willem H. Ouwehand, Alistair S. Hall, Panos Deloukas, John R. Thompson, Kari Stefansson, Robert Roberts, Unnur Thorsteinsdottir, Christopher J. O'Donnell, Ruth McPherson, Jeanette Erdmann, Nilesh J. Samani

Research output: Contribution to journalArticle

Abstract

We performed a meta-analysis of 14 genome-wide association studies of coronary artery disease (CAD) comprising 22,233 individuals with CAD (cases) and 64,762 controls of European descent followed by genotyping of top association signals in 56,682 additional individuals. This analysis identified 13 loci newly associated with CAD at P <5 - 10'8 and confirmed the association of 10 of 12 previously reported CAD loci. The 13 new loci showed risk allele frequencies ranging from 0.13 to 0.91 and were associated with a 6% to 17% increase in the risk of CAD per allele. Notably, only three of the new loci showed significant association with traditional CAD risk factors and the majority lie in gene regions not previously implicated in the pathogenesis of CAD. Finally, five of the new CAD risk loci appear to have pleiotropic effects, showing strong association with various other human diseases or traits.

Original languageEnglish (US)
Pages (from-to)333-340
Number of pages8
JournalNature Genetics
Volume43
Issue number4
DOIs
StatePublished - Feb 2011

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Coronary Artery Disease
Genome-Wide Association Study
Gene Frequency
Meta-Analysis
Alleles
Genes

ASJC Scopus subject areas

  • Genetics

Cite this

Schunkert, H., König, I. R., Kathiresan, S., Reilly, M. P., Assimes, T. L., Holm, H., ... Samani, N. J. (2011). Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nature Genetics, 43(4), 333-340. https://doi.org/10.1038/ng.784

Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. / Schunkert, Heribert; König, Inke R.; Kathiresan, Sekar; Reilly, Muredach P.; Assimes, Themistocles L.; Holm, Hilma; Preuss, Michael; Stewart, Alexandre F R; Barbalic, Maja; Gieger, Christian; Absher, Devin; Aherrahrou, Zouhair; Allayee, Hooman; Altshuler, David; Anand, Sonia S.; Andersen, Karl; Anderson, Jeffrey L.; Ardissino, Diego; Ball, Stephen G.; Balmforth, Anthony J.; Barnes, Timothy A.; Becker, Diane M; Becker, Lewis; Berger, Klaus; Bis, Joshua C.; Boekholdt, S. Matthijs; Boerwinkle, Eric; Braund, Peter S.; Brown, Morris J.; Burnett, Mary Susan; Buysschaert, Ian; Carlquist, John F.; Chen, Li; Cichon, Sven; Codd, Veryan; Davies, Robert W.; Dedoussis, George; Dehghan, Abbas; Demissie, Serkalem; Devaney, Joseph M.; Diemert, Patrick; Do, Ron; Doering, Angela; Eifert, Sandra; Mokhtari, Nour Eddine El; Ellis, Stephen G.; Elosua, Roberto; Engert, James C.; Epstein, Stephen E.; De Faire, Ulf; Fischer, Marcus; Folsom, Aaron R.; Freyer, Jennifer; Gigante, Bruna; Girelli, Domenico; Gretarsdottir, Solveig; Gudnason, Vilmundur; Gulcher, Jeffrey R.; Halperin, Eran; Hammond, Naomi; Hazen, Stanley L.; Hofman, Albert; Horne, Benjamin D.; Illig, Thomas; Iribarren, Carlos; Jones, Gregory T.; Jukema, J. Wouter; Kaiser, Michael A.; Kaplan, Lee M.; Kastelein, John J P; Khaw, Kay Tee; Knowles, Joshua W.; Kolovou, Genovefa; Kong, Augustine; Laaksonen, Reijo; Lambrechts, Diether; Leander, Karin; Lettre, Guillaume; Li, Mingyao; Lieb, Wolfgang; Loley, Christina; Lotery, Andrew J.; Mannucci, Pier M.; Maouche, Seraya; Martinelli, Nicola; McKeown, Pascal P.; Meisinger, Christa; Meitinger, Thomas; Melander, Olle; Merlini, Pier Angelica; Mooser, Vincent; Morgan, Thomas; Mühleisen, Thomas W.; Muhlestein, Joseph B.; Münzel, Thomas; Musunuru, Kiran; Nahrstaedt, Janja; Nelson, Christopher P.; Nöthen, Markus M.; Olivieri, Oliviero; Patel, Riyaz S.; Patterson, Chris C.; Peters, Annette; Peyvandi, Flora; Qu, Liming; Quyyumi, Arshed A.; Rader, Daniel J.; Rallidis, Loukianos S.; Rice, Catherine; Rosendaal, Frits R.; Rubin, Diana; Salomaa, Veikko; Sampietro, M. Lourdes; Sandhu, Manj S.; Schadt, Eric; Scḧsignfer, Arne; Schillert, Arne; Schreiber, Stefan; Schrezenmeir, Jürgen; Schwartz, Stephen M.; Siscovick, David S.; Sivananthan, Mohan; Sivapalaratnam, Suthesh; Smith, Albert; Smith, Tamara B.; Snoep, Jaapjan D.; Soranzo, Nicole; Spertus, John A.; Stark, Klaus; Stirrups, Kathy; Stoll, Monika; Tang, W. H Wilson; Tennstedt, Stephanie; Thorgeirsson, Gudmundur; Thorleifsson, Gudmar; Tomaszewski, MacIej; Uitterlinden, Andre G.; Van Rij, Andre M.; Voight, Benjamin F.; Wareham, Nick J.; Wells, George A.; Wichmann, H. Erich; Wild, Philipp S.; Willenborg, Christina; Witteman, Jaqueline C M; Wright, Benjamin J.; Ye, Shu; Zeller, Tanja; Ziegler, Andreas; Cambien, Francois; Goodall, Alison H.; Cupples, L. Adrienne; Quertermous, Thomas; Mäsignrz, Winfried; Hengstenberg, Christian; Blankenberg, Stefan; Ouwehand, Willem H.; Hall, Alistair S.; Deloukas, Panos; Thompson, John R.; Stefansson, Kari; Roberts, Robert; Thorsteinsdottir, Unnur; O'Donnell, Christopher J.; McPherson, Ruth; Erdmann, Jeanette; Samani, Nilesh J.

In: Nature Genetics, Vol. 43, No. 4, 02.2011, p. 333-340.

Research output: Contribution to journalArticle

Schunkert, H, König, IR, Kathiresan, S, Reilly, MP, Assimes, TL, Holm, H, Preuss, M, Stewart, AFR, Barbalic, M, Gieger, C, Absher, D, Aherrahrou, Z, Allayee, H, Altshuler, D, Anand, SS, Andersen, K, Anderson, JL, Ardissino, D, Ball, SG, Balmforth, AJ, Barnes, TA, Becker, DM, Becker, L, Berger, K, Bis, JC, Boekholdt, SM, Boerwinkle, E, Braund, PS, Brown, MJ, Burnett, MS, Buysschaert, I, Carlquist, JF, Chen, L, Cichon, S, Codd, V, Davies, RW, Dedoussis, G, Dehghan, A, Demissie, S, Devaney, JM, Diemert, P, Do, R, Doering, A, Eifert, S, Mokhtari, NEE, Ellis, SG, Elosua, R, Engert, JC, Epstein, SE, De Faire, U, Fischer, M, Folsom, AR, Freyer, J, Gigante, B, Girelli, D, Gretarsdottir, S, Gudnason, V, Gulcher, JR, Halperin, E, Hammond, N, Hazen, SL, Hofman, A, Horne, BD, Illig, T, Iribarren, C, Jones, GT, Jukema, JW, Kaiser, MA, Kaplan, LM, Kastelein, JJP, Khaw, KT, Knowles, JW, Kolovou, G, Kong, A, Laaksonen, R, Lambrechts, D, Leander, K, Lettre, G, Li, M, Lieb, W, Loley, C, Lotery, AJ, Mannucci, PM, Maouche, S, Martinelli, N, McKeown, PP, Meisinger, C, Meitinger, T, Melander, O, Merlini, PA, Mooser, V, Morgan, T, Mühleisen, TW, Muhlestein, JB, Münzel, T, Musunuru, K, Nahrstaedt, J, Nelson, CP, Nöthen, MM, Olivieri, O, Patel, RS, Patterson, CC, Peters, A, Peyvandi, F, Qu, L, Quyyumi, AA, Rader, DJ, Rallidis, LS, Rice, C, Rosendaal, FR, Rubin, D, Salomaa, V, Sampietro, ML, Sandhu, MS, Schadt, E, Scḧsignfer, A, Schillert, A, Schreiber, S, Schrezenmeir, J, Schwartz, SM, Siscovick, DS, Sivananthan, M, Sivapalaratnam, S, Smith, A, Smith, TB, Snoep, JD, Soranzo, N, Spertus, JA, Stark, K, Stirrups, K, Stoll, M, Tang, WHW, Tennstedt, S, Thorgeirsson, G, Thorleifsson, G, Tomaszewski, M, Uitterlinden, AG, Van Rij, AM, Voight, BF, Wareham, NJ, Wells, GA, Wichmann, HE, Wild, PS, Willenborg, C, Witteman, JCM, Wright, BJ, Ye, S, Zeller, T, Ziegler, A, Cambien, F, Goodall, AH, Cupples, LA, Quertermous, T, Mäsignrz, W, Hengstenberg, C, Blankenberg, S, Ouwehand, WH, Hall, AS, Deloukas, P, Thompson, JR, Stefansson, K, Roberts, R, Thorsteinsdottir, U, O'Donnell, CJ, McPherson, R, Erdmann, J & Samani, NJ 2011, 'Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease', Nature Genetics, vol. 43, no. 4, pp. 333-340. https://doi.org/10.1038/ng.784
Schunkert H, König IR, Kathiresan S, Reilly MP, Assimes TL, Holm H et al. Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nature Genetics. 2011 Feb;43(4):333-340. https://doi.org/10.1038/ng.784
Schunkert, Heribert ; König, Inke R. ; Kathiresan, Sekar ; Reilly, Muredach P. ; Assimes, Themistocles L. ; Holm, Hilma ; Preuss, Michael ; Stewart, Alexandre F R ; Barbalic, Maja ; Gieger, Christian ; Absher, Devin ; Aherrahrou, Zouhair ; Allayee, Hooman ; Altshuler, David ; Anand, Sonia S. ; Andersen, Karl ; Anderson, Jeffrey L. ; Ardissino, Diego ; Ball, Stephen G. ; Balmforth, Anthony J. ; Barnes, Timothy A. ; Becker, Diane M ; Becker, Lewis ; Berger, Klaus ; Bis, Joshua C. ; Boekholdt, S. Matthijs ; Boerwinkle, Eric ; Braund, Peter S. ; Brown, Morris J. ; Burnett, Mary Susan ; Buysschaert, Ian ; Carlquist, John F. ; Chen, Li ; Cichon, Sven ; Codd, Veryan ; Davies, Robert W. ; Dedoussis, George ; Dehghan, Abbas ; Demissie, Serkalem ; Devaney, Joseph M. ; Diemert, Patrick ; Do, Ron ; Doering, Angela ; Eifert, Sandra ; Mokhtari, Nour Eddine El ; Ellis, Stephen G. ; Elosua, Roberto ; Engert, James C. ; Epstein, Stephen E. ; De Faire, Ulf ; Fischer, Marcus ; Folsom, Aaron R. ; Freyer, Jennifer ; Gigante, Bruna ; Girelli, Domenico ; Gretarsdottir, Solveig ; Gudnason, Vilmundur ; Gulcher, Jeffrey R. ; Halperin, Eran ; Hammond, Naomi ; Hazen, Stanley L. ; Hofman, Albert ; Horne, Benjamin D. ; Illig, Thomas ; Iribarren, Carlos ; Jones, Gregory T. ; Jukema, J. Wouter ; Kaiser, Michael A. ; Kaplan, Lee M. ; Kastelein, John J P ; Khaw, Kay Tee ; Knowles, Joshua W. ; Kolovou, Genovefa ; Kong, Augustine ; Laaksonen, Reijo ; Lambrechts, Diether ; Leander, Karin ; Lettre, Guillaume ; Li, Mingyao ; Lieb, Wolfgang ; Loley, Christina ; Lotery, Andrew J. ; Mannucci, Pier M. ; Maouche, Seraya ; Martinelli, Nicola ; McKeown, Pascal P. ; Meisinger, Christa ; Meitinger, Thomas ; Melander, Olle ; Merlini, Pier Angelica ; Mooser, Vincent ; Morgan, Thomas ; Mühleisen, Thomas W. ; Muhlestein, Joseph B. ; Münzel, Thomas ; Musunuru, Kiran ; Nahrstaedt, Janja ; Nelson, Christopher P. ; Nöthen, Markus M. ; Olivieri, Oliviero ; Patel, Riyaz S. ; Patterson, Chris C. ; Peters, Annette ; Peyvandi, Flora ; Qu, Liming ; Quyyumi, Arshed A. ; Rader, Daniel J. ; Rallidis, Loukianos S. ; Rice, Catherine ; Rosendaal, Frits R. ; Rubin, Diana ; Salomaa, Veikko ; Sampietro, M. Lourdes ; Sandhu, Manj S. ; Schadt, Eric ; Scḧsignfer, Arne ; Schillert, Arne ; Schreiber, Stefan ; Schrezenmeir, Jürgen ; Schwartz, Stephen M. ; Siscovick, David S. ; Sivananthan, Mohan ; Sivapalaratnam, Suthesh ; Smith, Albert ; Smith, Tamara B. ; Snoep, Jaapjan D. ; Soranzo, Nicole ; Spertus, John A. ; Stark, Klaus ; Stirrups, Kathy ; Stoll, Monika ; Tang, W. H Wilson ; Tennstedt, Stephanie ; Thorgeirsson, Gudmundur ; Thorleifsson, Gudmar ; Tomaszewski, MacIej ; Uitterlinden, Andre G. ; Van Rij, Andre M. ; Voight, Benjamin F. ; Wareham, Nick J. ; Wells, George A. ; Wichmann, H. Erich ; Wild, Philipp S. ; Willenborg, Christina ; Witteman, Jaqueline C M ; Wright, Benjamin J. ; Ye, Shu ; Zeller, Tanja ; Ziegler, Andreas ; Cambien, Francois ; Goodall, Alison H. ; Cupples, L. Adrienne ; Quertermous, Thomas ; Mäsignrz, Winfried ; Hengstenberg, Christian ; Blankenberg, Stefan ; Ouwehand, Willem H. ; Hall, Alistair S. ; Deloukas, Panos ; Thompson, John R. ; Stefansson, Kari ; Roberts, Robert ; Thorsteinsdottir, Unnur ; O'Donnell, Christopher J. ; McPherson, Ruth ; Erdmann, Jeanette ; Samani, Nilesh J. / Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. In: Nature Genetics. 2011 ; Vol. 43, No. 4. pp. 333-340.
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title = "Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease",
abstract = "We performed a meta-analysis of 14 genome-wide association studies of coronary artery disease (CAD) comprising 22,233 individuals with CAD (cases) and 64,762 controls of European descent followed by genotyping of top association signals in 56,682 additional individuals. This analysis identified 13 loci newly associated with CAD at P <5 - 10'8 and confirmed the association of 10 of 12 previously reported CAD loci. The 13 new loci showed risk allele frequencies ranging from 0.13 to 0.91 and were associated with a 6{\%} to 17{\%} increase in the risk of CAD per allele. Notably, only three of the new loci showed significant association with traditional CAD risk factors and the majority lie in gene regions not previously implicated in the pathogenesis of CAD. Finally, five of the new CAD risk loci appear to have pleiotropic effects, showing strong association with various other human diseases or traits.",
author = "Heribert Schunkert and K{\"o}nig, {Inke R.} and Sekar Kathiresan and Reilly, {Muredach P.} and Assimes, {Themistocles L.} and Hilma Holm and Michael Preuss and Stewart, {Alexandre F R} and Maja Barbalic and Christian Gieger and Devin Absher and Zouhair Aherrahrou and Hooman Allayee and David Altshuler and Anand, {Sonia S.} and Karl Andersen and Anderson, {Jeffrey L.} and Diego Ardissino and Ball, {Stephen G.} and Balmforth, {Anthony J.} and Barnes, {Timothy A.} and Becker, {Diane M} and Lewis Becker and Klaus Berger and Bis, {Joshua C.} and Boekholdt, {S. Matthijs} and Eric Boerwinkle and Braund, {Peter S.} and Brown, {Morris J.} and Burnett, {Mary Susan} and Ian Buysschaert and Carlquist, {John F.} and Li Chen and Sven Cichon and Veryan Codd and Davies, {Robert W.} and George Dedoussis and Abbas Dehghan and Serkalem Demissie and Devaney, {Joseph M.} and Patrick Diemert and Ron Do and Angela Doering and Sandra Eifert and Mokhtari, {Nour Eddine El} and Ellis, {Stephen G.} and Roberto Elosua and Engert, {James C.} and Epstein, {Stephen E.} and {De Faire}, Ulf and Marcus Fischer and Folsom, {Aaron R.} and Jennifer Freyer and Bruna Gigante and Domenico Girelli and Solveig Gretarsdottir and Vilmundur Gudnason and Gulcher, {Jeffrey R.} and Eran Halperin and Naomi Hammond and Hazen, {Stanley L.} and Albert Hofman and Horne, {Benjamin D.} and Thomas Illig and Carlos Iribarren and Jones, {Gregory T.} and Jukema, {J. Wouter} and Kaiser, {Michael A.} and Kaplan, {Lee M.} and Kastelein, {John J P} and Khaw, {Kay Tee} and Knowles, {Joshua W.} and Genovefa Kolovou and Augustine Kong and Reijo Laaksonen and Diether Lambrechts and Karin Leander and Guillaume Lettre and Mingyao Li and Wolfgang Lieb and Christina Loley and Lotery, {Andrew J.} and Mannucci, {Pier M.} and Seraya Maouche and Nicola Martinelli and McKeown, {Pascal P.} and Christa Meisinger and Thomas Meitinger and Olle Melander and Merlini, {Pier Angelica} and Vincent Mooser and Thomas Morgan and M{\"u}hleisen, {Thomas W.} and Muhlestein, {Joseph B.} and Thomas M{\"u}nzel and Kiran Musunuru and Janja Nahrstaedt and Nelson, {Christopher P.} and N{\"o}then, {Markus M.} and Oliviero Olivieri and Patel, {Riyaz S.} and Patterson, {Chris C.} and Annette Peters and Flora Peyvandi and Liming Qu and Quyyumi, {Arshed A.} and Rader, {Daniel J.} and Rallidis, {Loukianos S.} and Catherine Rice and Rosendaal, {Frits R.} and Diana Rubin and Veikko Salomaa and Sampietro, {M. Lourdes} and Sandhu, {Manj S.} and Eric Schadt and Arne Scḧsignfer and Arne Schillert and Stefan Schreiber and J{\"u}rgen Schrezenmeir and Schwartz, {Stephen M.} and Siscovick, {David S.} and Mohan Sivananthan and Suthesh Sivapalaratnam and Albert Smith and Smith, {Tamara B.} and Snoep, {Jaapjan D.} and Nicole Soranzo and Spertus, {John A.} and Klaus Stark and Kathy Stirrups and Monika Stoll and Tang, {W. H Wilson} and Stephanie Tennstedt and Gudmundur Thorgeirsson and Gudmar Thorleifsson and MacIej Tomaszewski and Uitterlinden, {Andre G.} and {Van Rij}, {Andre M.} and Voight, {Benjamin F.} and Wareham, {Nick J.} and Wells, {George A.} and Wichmann, {H. Erich} and Wild, {Philipp S.} and Christina Willenborg and Witteman, {Jaqueline C M} and Wright, {Benjamin J.} and Shu Ye and Tanja Zeller and Andreas Ziegler and Francois Cambien and Goodall, {Alison H.} and Cupples, {L. Adrienne} and Thomas Quertermous and Winfried M{\"a}signrz and Christian Hengstenberg and Stefan Blankenberg and Ouwehand, {Willem H.} and Hall, {Alistair S.} and Panos Deloukas and Thompson, {John R.} and Kari Stefansson and Robert Roberts and Unnur Thorsteinsdottir and O'Donnell, {Christopher J.} and Ruth McPherson and Jeanette Erdmann and Samani, {Nilesh J.}",
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language = "English (US)",
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pages = "333--340",
journal = "Nature Genetics",
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TY - JOUR

T1 - Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease

AU - Schunkert, Heribert

AU - König, Inke R.

AU - Kathiresan, Sekar

AU - Reilly, Muredach P.

AU - Assimes, Themistocles L.

AU - Holm, Hilma

AU - Preuss, Michael

AU - Stewart, Alexandre F R

AU - Barbalic, Maja

AU - Gieger, Christian

AU - Absher, Devin

AU - Aherrahrou, Zouhair

AU - Allayee, Hooman

AU - Altshuler, David

AU - Anand, Sonia S.

AU - Andersen, Karl

AU - Anderson, Jeffrey L.

AU - Ardissino, Diego

AU - Ball, Stephen G.

AU - Balmforth, Anthony J.

AU - Barnes, Timothy A.

AU - Becker, Diane M

AU - Becker, Lewis

AU - Berger, Klaus

AU - Bis, Joshua C.

AU - Boekholdt, S. Matthijs

AU - Boerwinkle, Eric

AU - Braund, Peter S.

AU - Brown, Morris J.

AU - Burnett, Mary Susan

AU - Buysschaert, Ian

AU - Carlquist, John F.

AU - Chen, Li

AU - Cichon, Sven

AU - Codd, Veryan

AU - Davies, Robert W.

AU - Dedoussis, George

AU - Dehghan, Abbas

AU - Demissie, Serkalem

AU - Devaney, Joseph M.

AU - Diemert, Patrick

AU - Do, Ron

AU - Doering, Angela

AU - Eifert, Sandra

AU - Mokhtari, Nour Eddine El

AU - Ellis, Stephen G.

AU - Elosua, Roberto

AU - Engert, James C.

AU - Epstein, Stephen E.

AU - De Faire, Ulf

AU - Fischer, Marcus

AU - Folsom, Aaron R.

AU - Freyer, Jennifer

AU - Gigante, Bruna

AU - Girelli, Domenico

AU - Gretarsdottir, Solveig

AU - Gudnason, Vilmundur

AU - Gulcher, Jeffrey R.

AU - Halperin, Eran

AU - Hammond, Naomi

AU - Hazen, Stanley L.

AU - Hofman, Albert

AU - Horne, Benjamin D.

AU - Illig, Thomas

AU - Iribarren, Carlos

AU - Jones, Gregory T.

AU - Jukema, J. Wouter

AU - Kaiser, Michael A.

AU - Kaplan, Lee M.

AU - Kastelein, John J P

AU - Khaw, Kay Tee

AU - Knowles, Joshua W.

AU - Kolovou, Genovefa

AU - Kong, Augustine

AU - Laaksonen, Reijo

AU - Lambrechts, Diether

AU - Leander, Karin

AU - Lettre, Guillaume

AU - Li, Mingyao

AU - Lieb, Wolfgang

AU - Loley, Christina

AU - Lotery, Andrew J.

AU - Mannucci, Pier M.

AU - Maouche, Seraya

AU - Martinelli, Nicola

AU - McKeown, Pascal P.

AU - Meisinger, Christa

AU - Meitinger, Thomas

AU - Melander, Olle

AU - Merlini, Pier Angelica

AU - Mooser, Vincent

AU - Morgan, Thomas

AU - Mühleisen, Thomas W.

AU - Muhlestein, Joseph B.

AU - Münzel, Thomas

AU - Musunuru, Kiran

AU - Nahrstaedt, Janja

AU - Nelson, Christopher P.

AU - Nöthen, Markus M.

AU - Olivieri, Oliviero

AU - Patel, Riyaz S.

AU - Patterson, Chris C.

AU - Peters, Annette

AU - Peyvandi, Flora

AU - Qu, Liming

AU - Quyyumi, Arshed A.

AU - Rader, Daniel J.

AU - Rallidis, Loukianos S.

AU - Rice, Catherine

AU - Rosendaal, Frits R.

AU - Rubin, Diana

AU - Salomaa, Veikko

AU - Sampietro, M. Lourdes

AU - Sandhu, Manj S.

AU - Schadt, Eric

AU - Scḧsignfer, Arne

AU - Schillert, Arne

AU - Schreiber, Stefan

AU - Schrezenmeir, Jürgen

AU - Schwartz, Stephen M.

AU - Siscovick, David S.

AU - Sivananthan, Mohan

AU - Sivapalaratnam, Suthesh

AU - Smith, Albert

AU - Smith, Tamara B.

AU - Snoep, Jaapjan D.

AU - Soranzo, Nicole

AU - Spertus, John A.

AU - Stark, Klaus

AU - Stirrups, Kathy

AU - Stoll, Monika

AU - Tang, W. H Wilson

AU - Tennstedt, Stephanie

AU - Thorgeirsson, Gudmundur

AU - Thorleifsson, Gudmar

AU - Tomaszewski, MacIej

AU - Uitterlinden, Andre G.

AU - Van Rij, Andre M.

AU - Voight, Benjamin F.

AU - Wareham, Nick J.

AU - Wells, George A.

AU - Wichmann, H. Erich

AU - Wild, Philipp S.

AU - Willenborg, Christina

AU - Witteman, Jaqueline C M

AU - Wright, Benjamin J.

AU - Ye, Shu

AU - Zeller, Tanja

AU - Ziegler, Andreas

AU - Cambien, Francois

AU - Goodall, Alison H.

AU - Cupples, L. Adrienne

AU - Quertermous, Thomas

AU - Mäsignrz, Winfried

AU - Hengstenberg, Christian

AU - Blankenberg, Stefan

AU - Ouwehand, Willem H.

AU - Hall, Alistair S.

AU - Deloukas, Panos

AU - Thompson, John R.

AU - Stefansson, Kari

AU - Roberts, Robert

AU - Thorsteinsdottir, Unnur

AU - O'Donnell, Christopher J.

AU - McPherson, Ruth

AU - Erdmann, Jeanette

AU - Samani, Nilesh J.

PY - 2011/2

Y1 - 2011/2

N2 - We performed a meta-analysis of 14 genome-wide association studies of coronary artery disease (CAD) comprising 22,233 individuals with CAD (cases) and 64,762 controls of European descent followed by genotyping of top association signals in 56,682 additional individuals. This analysis identified 13 loci newly associated with CAD at P <5 - 10'8 and confirmed the association of 10 of 12 previously reported CAD loci. The 13 new loci showed risk allele frequencies ranging from 0.13 to 0.91 and were associated with a 6% to 17% increase in the risk of CAD per allele. Notably, only three of the new loci showed significant association with traditional CAD risk factors and the majority lie in gene regions not previously implicated in the pathogenesis of CAD. Finally, five of the new CAD risk loci appear to have pleiotropic effects, showing strong association with various other human diseases or traits.

AB - We performed a meta-analysis of 14 genome-wide association studies of coronary artery disease (CAD) comprising 22,233 individuals with CAD (cases) and 64,762 controls of European descent followed by genotyping of top association signals in 56,682 additional individuals. This analysis identified 13 loci newly associated with CAD at P <5 - 10'8 and confirmed the association of 10 of 12 previously reported CAD loci. The 13 new loci showed risk allele frequencies ranging from 0.13 to 0.91 and were associated with a 6% to 17% increase in the risk of CAD per allele. Notably, only three of the new loci showed significant association with traditional CAD risk factors and the majority lie in gene regions not previously implicated in the pathogenesis of CAD. Finally, five of the new CAD risk loci appear to have pleiotropic effects, showing strong association with various other human diseases or traits.

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U2 - 10.1038/ng.784

DO - 10.1038/ng.784

M3 - Article

VL - 43

SP - 333

EP - 340

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

IS - 4

ER -