TY - JOUR
T1 - Large outbreak of measles in a community with high vaccination coverage
T2 - Implications for the vaccination schedule
AU - Domínguez, Angela
AU - Torner, Nuria
AU - Barrabeig, Irene
AU - Rovira, Ariadna
AU - Rius, Cristina
AU - Cayla, Joan
AU - Plasencia, Elsa
AU - Minguell, Sofia
AU - Sala, M. Rosa
AU - Martínez, Ana
AU - Costa, Josep
AU - Mosquera, Mar
AU - Cabezas, Carmen
AU - Godoy, P.
AU - Batalla, J.
AU - Alvarez, J.
AU - Urbano, R.
AU - Arias, C.
AU - Torres, J.
AU - Camps, N.
AU - Urbitzondo, L.
AU - Jansà, J. M.
AU - Plasencia, A.
AU - Guix, J.
AU - Guarga, A.
AU - Sintes, X.
AU - Zabaleta, E.
AU - Jodar, G.
AU - Martinez, M. V.
AU - Peña-Rey, I.
AU - Castellanos, T.
AU - Echevarria, J. E.
AU - De Ory, F.
N1 - Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.
PY - 2008/11/1
Y1 - 2008/11/1
N2 - Background. Attempts to eliminate measles from a country or region may be disrupted by an imported case that affects indigenous persons. The objective of this study was to analyze epidemiological and clinical characteristics of a measles outbreak in Catalonia, Spain, in 2006. Methods. Data on cases of measles reported to the Department of Health, Generalitat of Catalonia, during the period 28 August 2006 through 8 July 2007 were collected. Suspected cases were confirmed by determination of measles-specific immunoglobulin M antibodies and/or detection of virus genome. Incidences were calculated using the estimated population of Catalonia for 2006, and 95% confidence intervals were determined assuming a Poisson distribution. The association between proportions was determined using the χ2 test and Fisher's exact test. The level of statistical significance was set at α = .05. Results. A total of 381 cases were confirmed, for an incidence of 6.6 cases per 100,000 persons. A total of 89.5% of cases occurred in nonvaccinated persons, mainly those aged ≤15 months (incidence, 278.2 cases per 100,000 persons; mean age of patients, 12 months). Indigenous subjects accounted for 89.8% of cases, and laboratory confirmation of results was obtained for 87.1%. Measles genotype D4 was identified in all sequenced samples. Conclusions. The age distribution of cases of measles among children aged <15 months suggests that the first dose of vaccine should be routinely administered at the age of 12 months.
AB - Background. Attempts to eliminate measles from a country or region may be disrupted by an imported case that affects indigenous persons. The objective of this study was to analyze epidemiological and clinical characteristics of a measles outbreak in Catalonia, Spain, in 2006. Methods. Data on cases of measles reported to the Department of Health, Generalitat of Catalonia, during the period 28 August 2006 through 8 July 2007 were collected. Suspected cases were confirmed by determination of measles-specific immunoglobulin M antibodies and/or detection of virus genome. Incidences were calculated using the estimated population of Catalonia for 2006, and 95% confidence intervals were determined assuming a Poisson distribution. The association between proportions was determined using the χ2 test and Fisher's exact test. The level of statistical significance was set at α = .05. Results. A total of 381 cases were confirmed, for an incidence of 6.6 cases per 100,000 persons. A total of 89.5% of cases occurred in nonvaccinated persons, mainly those aged ≤15 months (incidence, 278.2 cases per 100,000 persons; mean age of patients, 12 months). Indigenous subjects accounted for 89.8% of cases, and laboratory confirmation of results was obtained for 87.1%. Measles genotype D4 was identified in all sequenced samples. Conclusions. The age distribution of cases of measles among children aged <15 months suggests that the first dose of vaccine should be routinely administered at the age of 12 months.
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U2 - 10.1086/592258
DO - 10.1086/592258
M3 - Article
C2 - 18823269
AN - SCOPUS:53349118566
VL - 47
SP - 1143
EP - 1149
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
SN - 1058-4838
IS - 9
ER -