Large epidemic of cholera-like disease in Bangladesh caused by Vibrio cholerae 0139 synonym Bengal

M. J. Albert, M. Ansaruzzaman, P. K. Bardhan, A. S.G. Faruque, S. M. Faruque, M. S. Islam, D. Mahalanabis, R. B. Sack, M. A. Salam, A. K. Siddique, M. D. Yunus, K. Zaman

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Abstract

Epidemics of cholera caused by Vibrio cholerae 01 occur regularly in Bangladesh, but until lately V cholerae non-01 has been associated only with sporadic cases of diarrhoeal disease in many parts of the world, including Bangladesh. We describe a large epidemic of cholera-like disease in Bangladesh that is due to a V cholerae non-01. The epidemic began in December, 1992, in southern Bangladesh and spread throughout the country. By the end of March 107 297 cases of diarrhoea and 1473 deaths had been reported. The disease is indistinguishable from cholera in clinical features and response to treatment, but most of the cases are in adults, which suggests that the population has no previous immunological experience of the organism. At two centres 375 (40%) of 938 and 236 (48%) of 492 rectal swabs were positive for V cholerae non-01, as were 5 of 54 surface water samples. 55 isolates of V cholerae non-01 were studied in detail. They resembled El Tor vibrios in being resistant to polymyxin B and positive for agglutination of chicken erythrocytes. The strain did not belong to any of the 138 known V cholerae serogroups; so a new serogroup 0139, with the suggested name Bengal, is proposed. All the isolates studied produced large amounts of an enterotoxin apparently identical to cholera toxin. This strain seems to have pandemic potential. It is important that other countries in southeast Asia are aware of the strain's potential to cause severe morbidity and mortality.

Original languageEnglish (US)
Pages (from-to)387-390
Number of pages4
JournalThe Lancet
Volume342
Issue number8868
DOIs
StatePublished - Aug 14 1993

ASJC Scopus subject areas

  • Medicine(all)

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    Albert, M. J., Ansaruzzaman, M., Bardhan, P. K., Faruque, A. S. G., Faruque, S. M., Islam, M. S., Mahalanabis, D., Sack, R. B., Salam, M. A., Siddique, A. K., Yunus, M. D., & Zaman, K. (1993). Large epidemic of cholera-like disease in Bangladesh caused by Vibrio cholerae 0139 synonym Bengal. The Lancet, 342(8868), 387-390. https://doi.org/10.1016/0140-6736(93)92811-7