Large deformation of red blood cell ghosts in a simple shear flow

C. D. Eggleton, Aleksander S Popel

Research output: Contribution to journalArticle

Abstract

Red blood cells are known to change shape in response to local flow conditions. Deformability affects red blood cell physiological function and the hydrodynamic properties of blood. The immersed boundary method is used to simulate three-dimensional membrane-fluid flow interactions for cells with the same internal and external fluid viscosities. The method has been validated for small deformations of an initially spherical capsule in simple shear flow for both neo-Hookean and the Evans-Skalak membrane models. Initially oblate spheroidal capsules are simulated and it is shown that the red blood cell membrane exhibits asymptotic behavior as the ratio of the dilation modulus to the extensional modulus is increased and a good approximation of local area conservation is obtained. Tank treading behavior is observed and its period calculated.

Original languageEnglish (US)
Pages (from-to)1834-1845
Number of pages12
JournalPhysics of Fluids
Volume10
Issue number8
StatePublished - Aug 1998

Fingerprint

erythrocytes
Shear flow
ghosts
shear flow
Blood
Cells
capsules
membranes
Capsules
Membranes
Flow interactions
fluid flow
blood
conservation
Cell membranes
Formability
hydrodynamics
viscosity
Flow of fluids
Conservation

ASJC Scopus subject areas

  • Fluid Flow and Transfer Processes
  • Computational Mechanics
  • Mechanics of Materials
  • Physics and Astronomy(all)
  • Condensed Matter Physics

Cite this

Large deformation of red blood cell ghosts in a simple shear flow. / Eggleton, C. D.; Popel, Aleksander S.

In: Physics of Fluids, Vol. 10, No. 8, 08.1998, p. 1834-1845.

Research output: Contribution to journalArticle

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