Flat-panel x-ray imaging arrays based upon thin-film electronics are increasingly under development and investigation for a variety of applications. Our research has progressed to the point where three large area designs have now been fabricated, including a new 26 × 26 cm 2 array. These arrays are the largest self-scanning, solid-state imaging arrays thus far reported. In all probability, they represent only the first examples of an entirely new class of real-time imaging devices whose properties offer significant advantages over current radiographic and fluoroscopic x-ray technologies. A general overview of the current state of this emerging imaging technology is presented. Our large area array designs are described and x- ray images from a high resolution array are presented. Future challenges as well as anticipated trends and developments are discussed.