Language dysfunction in early- and late-onset possible alzheimer’s disease

Ola A. Selnes, Kathryn Carson, Barry Rovner, Barry Gordon

Research output: Contribution to journalArticle


Disproportionate involvement of language has been claimed to be a distinguishing feature of Alzheimer’s disease (AD) with onset before age 65. We tested this hypothesis in a group of 133 patients with possible AD by NINCDS criteria. Sixty-one had onset of symptoms prior to age 65; the remaining 72, at 65 or later. The two groups were well matched on overall dementia severity as measured by the Mini-Mental State Exam. Using standardized tests, we did not find any significant differences in the severity of language dysfunction between the two groups, particularly after controlling for greater attention/ concentration deficits in the early-onset group. Previous reports of differences in language dysfunction between early- and late-onset AD may have been due to small sample sizes and nonstandardized testing.

Original languageEnglish (US)
Pages (from-to)1053-1056
Number of pages4
Issue number7
StatePublished - Jul 1988

ASJC Scopus subject areas

  • Clinical Neurology

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