The presence of aphasia or agraphia easily detectable by a standard history and clinical examination of SDAT patients predicts a high risk of dementia in the parents and sibs of those patients. The appearance of dementia in about 50% of parents and sibs, regardless of sex, is compatible with autosomal dominant inheritance. Familial Alzheimer's disease is a clinicopathologic entity characterized by a dementia syndrome with prominent aphasia and agraphia. We suggest that it is an autosomal dominant disorder of complete but age-dependent penetrance and that this entity is the most frequent cause of dementia seen in clinical practice.
|Original language||English (US)|
|Number of pages||3|
|Journal||Johns Hopkins Medical Journal|
|State||Published - Dec 1 1981|
ASJC Scopus subject areas