Language disorder predicts familial Alzheimer's disease

M. F. Folstein, J. C.S. Breitner

Research output: Contribution to journalArticlepeer-review

66 Scopus citations


The presence of aphasia or agraphia easily detectable by a standard history and clinical examination of SDAT patients predicts a high risk of dementia in the parents and sibs of those patients. The appearance of dementia in about 50% of parents and sibs, regardless of sex, is compatible with autosomal dominant inheritance. Familial Alzheimer's disease is a clinicopathologic entity characterized by a dementia syndrome with prominent aphasia and agraphia. We suggest that it is an autosomal dominant disorder of complete but age-dependent penetrance and that this entity is the most frequent cause of dementia seen in clinical practice.

Original languageEnglish (US)
Pages (from-to)145-147
Number of pages3
JournalJohns Hopkins Medical Journal
Issue number4
StatePublished - 1981

ASJC Scopus subject areas

  • Medicine(all)


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