Abstract
The presence of aphasia or agraphia easily detectable by a standard history and clinical examination of SDAT patients predicts a high risk of dementia in the parents and sibs of those patients. The appearance of dementia in about 50% of parents and sibs, regardless of sex, is compatible with autosomal dominant inheritance. Familial Alzheimer's disease is a clinicopathologic entity characterized by a dementia syndrome with prominent aphasia and agraphia. We suggest that it is an autosomal dominant disorder of complete but age-dependent penetrance and that this entity is the most frequent cause of dementia seen in clinical practice.
Original language | English (US) |
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Pages (from-to) | 145-147 |
Number of pages | 3 |
Journal | Johns Hopkins Medical Journal |
Volume | 149 |
Issue number | 4 |
State | Published - 1981 |
ASJC Scopus subject areas
- General Medicine