Langerhans cell density and high-grade vulvar intraepithelial neoplasia in women with human immunodeficiency virus infection

Janis M Taube, Andrew D. Nichols, Lynette S. Bornman, Daniel M. Bornman, Jay Brooks Jackson

Research output: Contribution to journalArticle

Abstract

Background: Decreased numbers of Langerhans cells (LCs) in the cervix of human immunodeficiency virus (HIV)-infected women are believed to contribute to the progression of human papilloma virus (HPV)-related squamous intraepithelial lesions. However, this impairment of local immunity has not been well studied in the vulva. The objective of this study was to compare the S100+ LC density in high-grade vulvar intraepithelial neoplasia (VIN) in HIV-positive and HIV-negative women. Methods: HIV-positive and HIV-negative patients with high-grade VIN, 48 (55%) and 40 (45%), respectively, were identified by retrospective chart review. Smoking status of patients was noted. The mean LC count per high-power field (HPF) was determined using S100 immunohistochemical staining. In situ hybridization was performed to detect HPV DNA types 16 and 18. Results: Mean S100+ LC counts for HIV-positive and HIV-negative patients were 5.82 and 9.86 per HPF, respectively (p = 0.0026). LC counts in HIV-positive and HIV-negative patients were compared between smoking and nonsmoking groups (HIV-positive p = 0.4812, HIV-negative p = 0.2821). Conclusions: HIV-positive patients with high-grade VIN had significantly lower LC counts compared with HIV-negative patients. This suggests that local vulvar immunity as evaluated by S100+ LCs is impaired in HIV-positive women, possibly contributing to the progression of HPV-related vulvar lesions.

Original languageEnglish (US)
Pages (from-to)565-570
Number of pages6
JournalJournal of Cutaneous Pathology
Volume34
Issue number7
DOIs
StatePublished - Jul 2007

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Langerhans Cells
Virus Diseases
Cell Count
HIV
Neoplasms
Papillomaviridae
Immunity
Smoking
Vulva
Cervix Uteri
In Situ Hybridization

ASJC Scopus subject areas

  • Dermatology
  • Pathology and Forensic Medicine

Cite this

Langerhans cell density and high-grade vulvar intraepithelial neoplasia in women with human immunodeficiency virus infection. / Taube, Janis M; Nichols, Andrew D.; Bornman, Lynette S.; Bornman, Daniel M.; Jackson, Jay Brooks.

In: Journal of Cutaneous Pathology, Vol. 34, No. 7, 07.2007, p. 565-570.

Research output: Contribution to journalArticle

Taube, Janis M ; Nichols, Andrew D. ; Bornman, Lynette S. ; Bornman, Daniel M. ; Jackson, Jay Brooks. / Langerhans cell density and high-grade vulvar intraepithelial neoplasia in women with human immunodeficiency virus infection. In: Journal of Cutaneous Pathology. 2007 ; Vol. 34, No. 7. pp. 565-570.
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