Laminins and retinal vascular development

Malia M. Edwards, Olivier Lefebvre

Research output: Contribution to journalReview articlepeer-review

Abstract

The mechanisms controlling vascular development, both normal and pathological, are not yet fully understood. Many diseases, including cancer and diabetic retinopathy, involve abnormal blood vessel formation. Therefore, increasing knowledge of these mechanisms may help develop novel therapeutic targets. The identification of novel proteins or cells involved in this process would be particularly useful. The retina is an ideal model for studying vascular development because it is easy to access, particularly in rodents where this process occurs post-natally. Recent studies have suggested potential roles for laminin chains in vascular development of the retina. This review will provide an overview of these studies, demonstrating the importance of further research into the involvement of laminins in retinal blood vessel formation.

Original languageEnglish (US)
Pages (from-to)82-89
Number of pages8
JournalCell Adhesion and Migration
Volume7
Issue number1
DOIs
StatePublished - 2013

Keywords

  • Angiogenesis
  • Astrocytes
  • Blood vessels
  • Development
  • Laminin
  • Retina

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Cell Biology

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