Lamin-binding Proteins.

Katherine Lee Wilson, Roland Foisner

Research output: Contribution to journalArticle

Abstract

A- and B-type lamins are the major intermediate filaments of the nucleus. Lamins engage in a plethora of stable and transient interactions, near the inner nuclear membrane and throughout the nucleus. Lamin-binding proteins serve an amazingly diverse range of functions. Numerous inner-membrane proteins help anchor lamin filaments to the nuclear envelope, serving as part of the nuclear "lamina" network that is essential for nuclear architecture and integrity. Certain lamin-binding proteins of the inner membrane bind partners in the outer membrane and mechanically link lamins to the cytoskeleton. Inside the nucleus, lamin-binding proteins appear to serve as the "adaptors" by which the lamina organizes chromatin, influences gene expression and epigenetic regulation, and modulates signaling pathways. Transient interactions of lamins with key components of the transcription and replication machinery may provide an additional level of regulation or support to these essential events.

Original languageEnglish (US)
JournalCold Spring Harbor perspectives in biology
Volume2
Issue number4
DOIs
StatePublished - Apr 1 2010

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Lamins
Carrier Proteins
Nuclear Envelope
Membranes
Lamin Type B
Nuclear Lamina
Lamin Type A
Intermediate Filaments
Gene Expression Regulation
Transcription
Anchors
Cytoskeleton
Epigenomics
Gene expression
Chromatin
Machinery
Membrane Proteins

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Lamin-binding Proteins. / Wilson, Katherine Lee; Foisner, Roland.

In: Cold Spring Harbor perspectives in biology, Vol. 2, No. 4, 01.04.2010.

Research output: Contribution to journalArticle

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