Lamellipodia protrusion: Moving interactions of vinculin and Arp2/3

Susan W. Craig, Hui Chen

Research output: Contribution to journalArticle

Abstract

A direct, transient interaction between vinculin and Arp2/3 is required to promote receptor-stimulated lamellipodial extension and cell spreading. Vinculin selectively recruits Arp2/3 to the leading edge of the lamellipodium, where it may couple the actin polymerization machinery to adhesion complexes to promote membrane protrusion over ruffling.

Original languageEnglish (US)
JournalCurrent Biology
Volume13
Issue number6
DOIs
StatePublished - Mar 18 2003

Fingerprint

pseudopodia
Vinculin
Pseudopodia
polymerization
actin
adhesion
receptors
Polymerization
Machinery
Actins
Adhesion
cells
Membranes

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

Cite this

Lamellipodia protrusion : Moving interactions of vinculin and Arp2/3. / Craig, Susan W.; Chen, Hui.

In: Current Biology, Vol. 13, No. 6, 18.03.2003.

Research output: Contribution to journalArticle

Craig, Susan W. ; Chen, Hui. / Lamellipodia protrusion : Moving interactions of vinculin and Arp2/3. In: Current Biology. 2003 ; Vol. 13, No. 6.
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