LaeA, a regulator of morphogenetic fungal virulence factors

Woo Bok Jin, S. A. Balajee, Kieren A. Marr, David Andes, Kristian Fog Nielsen, Jens C. Frisvad, Nancy P. Keller

Research output: Contribution to journalArticlepeer-review

Abstract

Opportunistic animal and plant pathogens, well represented by the genus Aspergillus, have evolved unique mechanisms to adapt to and avoid host defenses. Aspergillus fumigatus, an increasingly serious pathogen owing to expanding numbers of immunocompromised patients, causes the majority of human infections; however, an inability to identify bona fide virulence factors has impeded therapeutic advances. We show that an A. fumigatus mutation in a developmentally expressed transcriptional regulator (ΔlaeA) coordinating morphological and chemical differentiation reduces virulence in a murine model; impaired virulence is associated with decreased levels of pulmonary gliotoxin and multiple changes in conidial and hyphal susceptibility to host phagocytes ex vivo. LaeA, a conserved protein in filamentous fungi, is a developmental regulator of virulence genes and, possibly, the first antimicrobial target specific to filamentous fungi that are pathogenic to plants and animals.

Original languageEnglish (US)
Pages (from-to)1574-1582
Number of pages9
JournalEukaryotic Cell
Volume4
Issue number9
DOIs
StatePublished - Sep 2005

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology

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