LaeA, a regulator of morphogenetic fungal virulence factors

Woo Bok Jin, S. A. Balajee, Kieren Marr, David Andes, Kristian Fog Nielsen, Jens C. Frisvad, Nancy P. Keller

Research output: Contribution to journalArticle

Abstract

Opportunistic animal and plant pathogens, well represented by the genus Aspergillus, have evolved unique mechanisms to adapt to and avoid host defenses. Aspergillus fumigatus, an increasingly serious pathogen owing to expanding numbers of immunocompromised patients, causes the majority of human infections; however, an inability to identify bona fide virulence factors has impeded therapeutic advances. We show that an A. fumigatus mutation in a developmentally expressed transcriptional regulator (ΔlaeA) coordinating morphological and chemical differentiation reduces virulence in a murine model; impaired virulence is associated with decreased levels of pulmonary gliotoxin and multiple changes in conidial and hyphal susceptibility to host phagocytes ex vivo. LaeA, a conserved protein in filamentous fungi, is a developmental regulator of virulence genes and, possibly, the first antimicrobial target specific to filamentous fungi that are pathogenic to plants and animals.

Original languageEnglish (US)
Pages (from-to)1574-1582
Number of pages9
JournalEukaryotic Cell
Volume4
Issue number9
DOIs
StatePublished - Sep 2005
Externally publishedYes

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Virulence Factors
Virulence
Aspergillus fumigatus
virulence
Fungi
Gliotoxin
Developmental Genes
Immunocompromised Host
Aspergillus
Regulator Genes
Phagocytes
animal pathogens
fungi
phagocytes
plant pathogens
Lung
Mutation
transcription factors
anti-infective agents
animal models

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Microbiology

Cite this

Jin, W. B., Balajee, S. A., Marr, K., Andes, D., Nielsen, K. F., Frisvad, J. C., & Keller, N. P. (2005). LaeA, a regulator of morphogenetic fungal virulence factors. Eukaryotic Cell, 4(9), 1574-1582. https://doi.org/10.1128/EC.4.9.1574-1582.2005

LaeA, a regulator of morphogenetic fungal virulence factors. / Jin, Woo Bok; Balajee, S. A.; Marr, Kieren; Andes, David; Nielsen, Kristian Fog; Frisvad, Jens C.; Keller, Nancy P.

In: Eukaryotic Cell, Vol. 4, No. 9, 09.2005, p. 1574-1582.

Research output: Contribution to journalArticle

Jin, WB, Balajee, SA, Marr, K, Andes, D, Nielsen, KF, Frisvad, JC & Keller, NP 2005, 'LaeA, a regulator of morphogenetic fungal virulence factors', Eukaryotic Cell, vol. 4, no. 9, pp. 1574-1582. https://doi.org/10.1128/EC.4.9.1574-1582.2005
Jin WB, Balajee SA, Marr K, Andes D, Nielsen KF, Frisvad JC et al. LaeA, a regulator of morphogenetic fungal virulence factors. Eukaryotic Cell. 2005 Sep;4(9):1574-1582. https://doi.org/10.1128/EC.4.9.1574-1582.2005
Jin, Woo Bok ; Balajee, S. A. ; Marr, Kieren ; Andes, David ; Nielsen, Kristian Fog ; Frisvad, Jens C. ; Keller, Nancy P. / LaeA, a regulator of morphogenetic fungal virulence factors. In: Eukaryotic Cell. 2005 ; Vol. 4, No. 9. pp. 1574-1582.
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