Lactosylceramide synthase as a therapeutic target to mitigate multiple human diseases in animal models

Subroto Chatterjee, Nezar Alsaeedi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Lactosylceramide synthases (LCSs; UDP-Gal: glucosylceramide β-1,4-galactosyltransferase) are integral membrane proteins of the Golgi apparatus. Recent developments in this area of research point to the suggestion that many physiological molecules can activate this enzyme to generate a glycosphingolipid (GSL), lactosylceramide (LacCer), which can induce critical phenotypes such as cell proliferation, migration, adhesion, angiogenesis, and apoptosis. In this chapter, we review the historical and scientific developments that unraveled the properties and molecular biology of LCSs. We also discuss the roles of LCSs in signaling pathways in disease development and how targeting LCS can be useful to cure many human diseases in animal models.

Original languageEnglish (US)
Title of host publicationBiochemical Roles of Eukaryotic Cell Surface Macromolecules
Subtitle of host publication2011 ISCSM Proceedings
EditorsPerumana Sudhakaran, Avadhesha Surolia, Avadhesha Surolia
Pages153-169
Number of pages17
DOIs
StatePublished - 2012

Publication series

NameAdvances in Experimental Medicine and Biology
Volume749
ISSN (Print)0065-2598

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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