Lactosylceramide synthase as a therapeutic target to mitigate multiple human diseases in animal models

Subroto Chatterjee; Nezar Alsaeedi

doi:10.1007/978-1-4614-3381-1_11

Lactosylceramide synthase as a therapeutic target to mitigate multiple human diseases in animal models

Subroto Chatterjee, Nezar Alsaeedi

School of Medicine

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

9 Scopus citations

Abstract

Lactosylceramide synthases (LCSs; UDP-Gal: glucosylceramide β-1,4-galactosyltransferase) are integral membrane proteins of the Golgi apparatus. Recent developments in this area of research point to the suggestion that many physiological molecules can activate this enzyme to generate a glycosphingolipid (GSL), lactosylceramide (LacCer), which can induce critical phenotypes such as cell proliferation, migration, adhesion, angiogenesis, and apoptosis. In this chapter, we review the historical and scientific developments that unraveled the properties and molecular biology of LCSs. We also discuss the roles of LCSs in signaling pathways in disease development and how targeting LCS can be useful to cure many human diseases in animal models.

Original language	English (US)
Title of host publication	Biochemical Roles of Eukaryotic Cell Surface Macromolecules
Subtitle of host publication	2011 ISCSM Proceedings
Editors	Perumana Sudhakaran, Avadhesha Surolia, Avadhesha Surolia
Pages	153-169
Number of pages	17
DOIs	https://doi.org/10.1007/978-1-4614-3381-1_11
State	Published - 2012

Publication series

Name	Advances in Experimental Medicine and Biology
Volume	749
ISSN (Print)	0065-2598

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1007/978-1-4614-3381-1_11

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Chatterjee, S., & Alsaeedi, N. (2012). Lactosylceramide synthase as a therapeutic target to mitigate multiple human diseases in animal models. In P. Sudhakaran, A. Surolia, & A. Surolia (Eds.), Biochemical Roles of Eukaryotic Cell Surface Macromolecules: 2011 ISCSM Proceedings (pp. 153-169). (Advances in Experimental Medicine and Biology; Vol. 749). https://doi.org/10.1007/978-1-4614-3381-1_11

Lactosylceramide synthase as a therapeutic target to mitigate multiple human diseases in animal models. / Chatterjee, Subroto; Alsaeedi, Nezar.
Biochemical Roles of Eukaryotic Cell Surface Macromolecules: 2011 ISCSM Proceedings. ed. / Perumana Sudhakaran; Avadhesha Surolia; Avadhesha Surolia. 2012. p. 153-169 (Advances in Experimental Medicine and Biology; Vol. 749).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Chatterjee, S & Alsaeedi, N 2012, Lactosylceramide synthase as a therapeutic target to mitigate multiple human diseases in animal models. in P Sudhakaran, A Surolia & A Surolia (eds), Biochemical Roles of Eukaryotic Cell Surface Macromolecules: 2011 ISCSM Proceedings. Advances in Experimental Medicine and Biology, vol. 749, pp. 153-169. https://doi.org/10.1007/978-1-4614-3381-1_11

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Lactosylceramide synthase as a therapeutic target to mitigate multiple human diseases in animal models

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