Lactoperoxidase-catalyzed lodination of arachidonic acid: Formation of macrolides

J. M. Boeynaems; D. Reagan; W. C. Hubbard

doi:10.1007/BF02535024

Lactoperoxidase-catalyzed lodination of arachidonic acid: Formation of macrolides

J. M. Boeynaems, D. Reagan, W. C. Hubbard

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

In the presence of iodide and hydrogen peroxide, lactoperoxidase catalyzed the conversion of arachidonic acid into several iodinated products; the major one was previously identified as an iodo-δ-lactone. Two minor and less polar products have now been characterized as 15-iodo-14-hydroxyeicosatrienoic acid, ω-lactone and 14-iodo-15-hydroxyeicosatrienoic acid, ω-lactone, on the basis of¹²⁵I incorporation, mass spectrometry, proton magnetic resonance spectroscopy and chemical modifications.

Original language	English (US)
Pages (from-to)	246-249
Number of pages	4
Journal	Lipids
Volume	16
Issue number	4
DOIs	https://doi.org/10.1007/BF02535024
State	Published - Apr 1981

ASJC Scopus subject areas

Biochemistry
Organic Chemistry
Cell Biology

Access to Document

10.1007/BF02535024

Cite this

@article{a83d88e6864143769ebc95e61caaff24,

title = "Lactoperoxidase-catalyzed lodination of arachidonic acid: Formation of macrolides",

abstract = "In the presence of iodide and hydrogen peroxide, lactoperoxidase catalyzed the conversion of arachidonic acid into several iodinated products; the major one was previously identified as an iodo-δ-lactone. Two minor and less polar products have now been characterized as 15-iodo-14-hydroxyeicosatrienoic acid, ω-lactone and 14-iodo-15-hydroxyeicosatrienoic acid, ω-lactone, on the basis of125I incorporation, mass spectrometry, proton magnetic resonance spectroscopy and chemical modifications.",

author = "Boeynaems, {J. M.} and D. Reagan and Hubbard, {W. C.}",

year = "1981",

month = apr,

doi = "10.1007/BF02535024",

language = "English (US)",

volume = "16",

pages = "246--249",

journal = "Lipids",

issn = "0024-4201",

publisher = "Springer Verlag",

number = "4",

}

TY - JOUR

T1 - Lactoperoxidase-catalyzed lodination of arachidonic acid

T2 - Formation of macrolides

AU - Boeynaems, J. M.

AU - Reagan, D.

AU - Hubbard, W. C.

PY - 1981/4

Y1 - 1981/4

N2 - In the presence of iodide and hydrogen peroxide, lactoperoxidase catalyzed the conversion of arachidonic acid into several iodinated products; the major one was previously identified as an iodo-δ-lactone. Two minor and less polar products have now been characterized as 15-iodo-14-hydroxyeicosatrienoic acid, ω-lactone and 14-iodo-15-hydroxyeicosatrienoic acid, ω-lactone, on the basis of125I incorporation, mass spectrometry, proton magnetic resonance spectroscopy and chemical modifications.

AB - In the presence of iodide and hydrogen peroxide, lactoperoxidase catalyzed the conversion of arachidonic acid into several iodinated products; the major one was previously identified as an iodo-δ-lactone. Two minor and less polar products have now been characterized as 15-iodo-14-hydroxyeicosatrienoic acid, ω-lactone and 14-iodo-15-hydroxyeicosatrienoic acid, ω-lactone, on the basis of125I incorporation, mass spectrometry, proton magnetic resonance spectroscopy and chemical modifications.

UR - http://www.scopus.com/inward/record.url?scp=0019558717&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019558717&partnerID=8YFLogxK

U2 - 10.1007/BF02535024

DO - 10.1007/BF02535024

M3 - Article

C2 - 6787360

AN - SCOPUS:0019558717

VL - 16

SP - 246

EP - 249

JO - Lipids

JF - Lipids

SN - 0024-4201

IS - 4

ER -

Lactoperoxidase-catalyzed lodination of arachidonic acid: Formation of macrolides

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this