Lactoperoxidase-catalyzed lodination of arachidonic acid: Formation of macrolides

J. M. Boeynaems, D. Reagan, W. C. Hubbard

Research output: Contribution to journalArticlepeer-review


In the presence of iodide and hydrogen peroxide, lactoperoxidase catalyzed the conversion of arachidonic acid into several iodinated products; the major one was previously identified as an iodo-δ-lactone. Two minor and less polar products have now been characterized as 15-iodo-14-hydroxyeicosatrienoic acid, ω-lactone and 14-iodo-15-hydroxyeicosatrienoic acid, ω-lactone, on the basis of125I incorporation, mass spectrometry, proton magnetic resonance spectroscopy and chemical modifications.

Original languageEnglish (US)
Pages (from-to)246-249
Number of pages4
Issue number4
StatePublished - Apr 1981

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Cell Biology


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