Lactate Transport and Receptor Actions in Retina

Potential Roles in Retinal Function and Disease

Miriam Kolko, Fia Vosborg, Ulrik L. Henriksen, Md Mahdi Hasan-Olive, Elisabeth Holm Diget, Rupali Vohra, Iswariya Raja Sridevi Gurubaran, Albert Gjedde, Shelton Tendai Mariga, Dorte M. Skytt, Tor Paaske Utheim, Jon Storm-Mathisen, Linda H. Bergersen

Research output: Contribution to journalArticle

Abstract

In retina, like in brain, lactate equilibrates across cell membranes via monocarboxylate transporters and in the extracellular space by diffusion, forming a basis for the action of lactate as a transmitter of metabolic signals. In the present paper, we argue that the lactate receptor GPR81, also known as HCAR1, may contribute importantly to the control of retinal cell functions in health and disease. GPR81, a G-protein coupled receptor, is known to downregulate cAMP both in adipose and nervous tissue. The receptor also acts through other down-stream mechanisms to control functions, such as excitability, metabolism and inflammation. Recent publications predict effects of the lactate receptor on neurodegeneration. Neurodegenerative diseases in retina, where the retinal ganglion cells die, notably glaucoma and diabetic retinopathy, may be linked to disturbed lactate homeostasis. Pilot studies reveal high GPR81 mRNA in retina and indicate GPR81 localization in Müller cells and retinal ganglion cells. Moreover, monocarboxylate transporters are expressed in retinal cells. We envision that lactate receptors and transporters could be useful future targets of novel therapeutic strategies to protect neurons and prevent or counteract glaucoma as well as other retinal diseases.

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalNeurochemical Research
DOIs
StateAccepted/In press - Dec 16 2015
Externally publishedYes

Fingerprint

Retinal Diseases
Retina
Lactic Acid
Retinal Ganglion Cells
Glaucoma
Monocarboxylic Acid Transporters
Nerve Tissue
Cells
Neurodegenerative diseases
Extracellular Space
Diabetic Retinopathy
G-Protein-Coupled Receptors
Neurodegenerative Diseases
Cell membranes
Adipose Tissue
Metabolism
Homeostasis
Down-Regulation
Neurons
Cell Membrane

Keywords

  • Diabetes retinopathy
  • Energy metabolism
  • Glaucoma
  • Lactate receptor
  • Lactate transport
  • Retina
  • Transmitter

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Biochemistry

Cite this

Kolko, M., Vosborg, F., Henriksen, U. L., Hasan-Olive, M. M., Diget, E. H., Vohra, R., ... Bergersen, L. H. (Accepted/In press). Lactate Transport and Receptor Actions in Retina: Potential Roles in Retinal Function and Disease. Neurochemical Research, 1-8. https://doi.org/10.1007/s11064-015-1792-x

Lactate Transport and Receptor Actions in Retina : Potential Roles in Retinal Function and Disease. / Kolko, Miriam; Vosborg, Fia; Henriksen, Ulrik L.; Hasan-Olive, Md Mahdi; Diget, Elisabeth Holm; Vohra, Rupali; Gurubaran, Iswariya Raja Sridevi; Gjedde, Albert; Mariga, Shelton Tendai; Skytt, Dorte M.; Utheim, Tor Paaske; Storm-Mathisen, Jon; Bergersen, Linda H.

In: Neurochemical Research, 16.12.2015, p. 1-8.

Research output: Contribution to journalArticle

Kolko, M, Vosborg, F, Henriksen, UL, Hasan-Olive, MM, Diget, EH, Vohra, R, Gurubaran, IRS, Gjedde, A, Mariga, ST, Skytt, DM, Utheim, TP, Storm-Mathisen, J & Bergersen, LH 2015, 'Lactate Transport and Receptor Actions in Retina: Potential Roles in Retinal Function and Disease', Neurochemical Research, pp. 1-8. https://doi.org/10.1007/s11064-015-1792-x
Kolko, Miriam ; Vosborg, Fia ; Henriksen, Ulrik L. ; Hasan-Olive, Md Mahdi ; Diget, Elisabeth Holm ; Vohra, Rupali ; Gurubaran, Iswariya Raja Sridevi ; Gjedde, Albert ; Mariga, Shelton Tendai ; Skytt, Dorte M. ; Utheim, Tor Paaske ; Storm-Mathisen, Jon ; Bergersen, Linda H. / Lactate Transport and Receptor Actions in Retina : Potential Roles in Retinal Function and Disease. In: Neurochemical Research. 2015 ; pp. 1-8.
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