Lacrimal gland autoimmunity in New Zealand mice.

K. F. Tabbara, Y. Ohashi

Research output: Contribution to journalArticlepeer-review

Abstract

We studied the spleen cell-mediated as well as antibody-mediated cytotoxicity to lacrimal gland acinar cells in New Zealand mice, an excellent animal model of Sjögren's syndrome. We found no difference in spleen cell-mediated cytotoxicity between young (3 months old) and old (6 to 12 months old) animals. With age, however, New Zealand mice developed an increasing level of serum autoantibodies to the lacrimal gland acinar cells. Such antibodies may play a role in the tissue damage of the lacrimal gland in these mice.

Original languageEnglish (US)
Pages (from-to)153-163
Number of pages11
JournalInternational Ophthalmology Clinics
Volume25
Issue number2
StatePublished - Jun 1985
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology

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