Lack of shunt response in suspected idiopathic normal pressure hydrocephalus with Alzheimer disease pathology

Roy Hamilton, Sunil Patel, Edward B. Lee, Eric M. Jackson, Joanna Lopinto, Steven E. Arnold, Christopher M. Clark, Anuj Basil, Leslie M. Shaw, Sharon X. Xie, M. Sean Grady, John Q. Trojanowski

Research output: Contribution to journalArticle

Abstract

To determine the impact of cortical Alzheimer disease pathology on shunt responsiveness in individuals treated for idiopathic normal pressure hydrocephalus (iNPH), 37 patients clinically diagnosed with iNPH participated in a prospective study in which performance on neurologic, psychometric, and gait measures before and 4 months after shunting was correlated with amyloid β plaques, neuritic plaques, and neurofibrillary tangles observed in cortical biopsies obtained during shunt insertion. No complications resulted from biopsy acquisition. Moderate to severe pathology was associated with worse baseline cognitive performance and diminished postoperative improvement on NPH symptom severity scales, gait measures, and cognitive instruments compared to patients lacking pathology.

Original languageEnglish (US)
Pages (from-to)535-540
Number of pages6
JournalAnnals of neurology
Volume68
Issue number4
DOIs
StatePublished - Oct 1 2010
Externally publishedYes

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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  • Cite this

    Hamilton, R., Patel, S., Lee, E. B., Jackson, E. M., Lopinto, J., Arnold, S. E., Clark, C. M., Basil, A., Shaw, L. M., Xie, S. X., Grady, M. S., & Trojanowski, J. Q. (2010). Lack of shunt response in suspected idiopathic normal pressure hydrocephalus with Alzheimer disease pathology. Annals of neurology, 68(4), 535-540. https://doi.org/10.1002/ana.22015