Lack of serological evidence for an association between simian virus 40 and lymphoma

Silvia De Sanjose, Keerti V. Shah, Eva Domingo-Domenech, Eric A. Engels, Alberto Fernandez De Sevilla, Tomas Alvaro, Mercedes Garcia-Villanueva, Vicens Romagosa, Eva Gonzalez-Barca, Raphael P. Viscidi

Research output: Contribution to journalArticle

Abstract

Recent studies have implicated simian virus 40 (SV40) in non-Hodgkin's lymphomas based on detection of SV40 DNA sequences. We employed a virus-like-particle (VLP)-based enzyme immunoassay for antibodies to SV40 to test sera from 520 lymphoma cases and 587 controls in Spain. The SV40 seroprevalence was 9.5% in controls and 5.9% in cases. Antibody levels of the positive sera were low. There was no association of SV40 seropositivity with any subtype of lymphoma. VLPs of the human BK virus substantially inhibited the SV40 reactivity of human sera. There was no serological evidence of widespread SV40 infection and no association of SV40 seropositivity with human lymphomas in Spain.

Original languageEnglish (US)
Pages (from-to)522-524
Number of pages3
JournalInternational Journal of Cancer
Volume104
Issue number4
DOIs
StatePublished - Apr 20 2003

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    De Sanjose, S., Shah, K. V., Domingo-Domenech, E., Engels, E. A., De Sevilla, A. F., Alvaro, T., Garcia-Villanueva, M., Romagosa, V., Gonzalez-Barca, E., & Viscidi, R. P. (2003). Lack of serological evidence for an association between simian virus 40 and lymphoma. International Journal of Cancer, 104(4), 522-524. https://doi.org/10.1002/ijc.10993