Lack of serological evidence for an association between simian virus 40 and lymphoma

Silvia De Sanjose; Keerti V. Shah; Eva Domingo-Domenech; Eric A. Engels; Alberto Fernandez De Sevilla; Tomas Alvaro; Mercedes Garcia-Villanueva; Vicens Romagosa; Eva Gonzalez-Barca; Raphael P. Viscidi

doi:10.1002/ijc.10993

Lack of serological evidence for an association between simian virus 40 and lymphoma

Silvia De Sanjose, Keerti V. Shah, Eva Domingo-Domenech, Eric A. Engels, Alberto Fernandez De Sevilla, Tomas Alvaro, Mercedes Garcia-Villanueva, Vicens Romagosa, Eva Gonzalez-Barca, Raphael P. Viscidi

School of Medicine

Research output: Contribution to journal › Article › peer-review

60 Scopus citations

Abstract

Recent studies have implicated simian virus 40 (SV40) in non-Hodgkin's lymphomas based on detection of SV40 DNA sequences. We employed a virus-like-particle (VLP)-based enzyme immunoassay for antibodies to SV40 to test sera from 520 lymphoma cases and 587 controls in Spain. The SV40 seroprevalence was 9.5% in controls and 5.9% in cases. Antibody levels of the positive sera were low. There was no association of SV40 seropositivity with any subtype of lymphoma. VLPs of the human BK virus substantially inhibited the SV40 reactivity of human sera. There was no serological evidence of widespread SV40 infection and no association of SV40 seropositivity with human lymphomas in Spain.

Original language	English (US)
Pages (from-to)	522-524
Number of pages	3
Journal	International Journal of Cancer
Volume	104
Issue number	4
DOIs	https://doi.org/10.1002/ijc.10993
State	Published - Apr 20 2003

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1002/ijc.10993

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title = "Lack of serological evidence for an association between simian virus 40 and lymphoma",

abstract = "Recent studies have implicated simian virus 40 (SV40) in non-Hodgkin's lymphomas based on detection of SV40 DNA sequences. We employed a virus-like-particle (VLP)-based enzyme immunoassay for antibodies to SV40 to test sera from 520 lymphoma cases and 587 controls in Spain. The SV40 seroprevalence was 9.5% in controls and 5.9% in cases. Antibody levels of the positive sera were low. There was no association of SV40 seropositivity with any subtype of lymphoma. VLPs of the human BK virus substantially inhibited the SV40 reactivity of human sera. There was no serological evidence of widespread SV40 infection and no association of SV40 seropositivity with human lymphomas in Spain.",

author = "{De Sanjose}, Silvia and Shah, {Keerti V.} and Eva Domingo-Domenech and Engels, {Eric A.} and {De Sevilla}, {Alberto Fernandez} and Tomas Alvaro and Mercedes Garcia-Villanueva and Vicens Romagosa and Eva Gonzalez-Barca and Viscidi, {Raphael P.}",

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T1 - Lack of serological evidence for an association between simian virus 40 and lymphoma

AU - De Sanjose, Silvia

AU - Shah, Keerti V.

AU - Domingo-Domenech, Eva

AU - Engels, Eric A.

AU - De Sevilla, Alberto Fernandez

AU - Alvaro, Tomas

AU - Garcia-Villanueva, Mercedes

AU - Romagosa, Vicens

AU - Gonzalez-Barca, Eva

AU - Viscidi, Raphael P.

PY - 2003/4/20

Y1 - 2003/4/20

N2 - Recent studies have implicated simian virus 40 (SV40) in non-Hodgkin's lymphomas based on detection of SV40 DNA sequences. We employed a virus-like-particle (VLP)-based enzyme immunoassay for antibodies to SV40 to test sera from 520 lymphoma cases and 587 controls in Spain. The SV40 seroprevalence was 9.5% in controls and 5.9% in cases. Antibody levels of the positive sera were low. There was no association of SV40 seropositivity with any subtype of lymphoma. VLPs of the human BK virus substantially inhibited the SV40 reactivity of human sera. There was no serological evidence of widespread SV40 infection and no association of SV40 seropositivity with human lymphomas in Spain.

AB - Recent studies have implicated simian virus 40 (SV40) in non-Hodgkin's lymphomas based on detection of SV40 DNA sequences. We employed a virus-like-particle (VLP)-based enzyme immunoassay for antibodies to SV40 to test sera from 520 lymphoma cases and 587 controls in Spain. The SV40 seroprevalence was 9.5% in controls and 5.9% in cases. Antibody levels of the positive sera were low. There was no association of SV40 seropositivity with any subtype of lymphoma. VLPs of the human BK virus substantially inhibited the SV40 reactivity of human sera. There was no serological evidence of widespread SV40 infection and no association of SV40 seropositivity with human lymphomas in Spain.

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JO - International Journal of Cancer

JF - International Journal of Cancer

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Lack of serological evidence for an association between simian virus 40 and lymphoma

Abstract

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