Lack of over-expression of T cell receptor Vβ5.2 in myelin basic protein-specific T cell lines derived from HLA-DR2 positive multiple sclerosis patients and controls

Ghazaleh Afshar, Paolo A. Muraro, Henry F. McFarland, Roland Martin

Research output: Contribution to journalArticlepeer-review

Abstract

Based on studies reporting an overexpression of certain V genes in myelin basic protein (MBP)-specific T cells from MS patients, immunotherapies targeting single TCR (Vβ5.2, Vβ6.1) are currently under way. In order to assess the basic assumption for one of these therapeutic strategies, i.e. the overexpression of Vβ5.2 by MBP-specific T cells, we analyzed 100 MBP- specific T cell lines (TCL) for Vβ5.2 expression. Only 4 out of 100 TCL expressed Vβ5.2, and expression of this TCR gene is therefore not more frequent than expected from the normal peripheral blood distribution.

Original languageEnglish (US)
Pages (from-to)7-13
Number of pages7
JournalJournal of Neuroimmunology
Volume84
Issue number1
DOIs
StatePublished - Apr 1 1998
Externally publishedYes

Keywords

  • CD4-positive T-lymphocytes
  • HLA-DR2 antigens
  • Multiple sclerosis
  • Myelin basic proteins
  • T-cell receptors

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

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