Lack of linkage or association between schizophrenia and the polymorphic trinucleotide repeat within the KCNN3 gene on chromosome 1q21

Stylianos E. Antonarakis, Jean Louis Blouin, Virginia K. Lasseter, Corinne Gehrig, Uppala Radhakrishna, Gerry Nestadt, David E. Housman, Haig H. Kazazian, Katalin Kalman, George Gutman, Emmanuel Fantino, K. George Chandy, J. Jay Gargus, Ann E. Pulver

Research output: Contribution to journalArticlepeer-review

Abstract

To determine the importance of a candidate gene KCNN3 (formerly named hSKCa3) in the susceptibility to schizophrenia, we have studied the genotypes of a (CAG)n polymorphism within this gene in the DNAs of the members of 54 multiplex families with this disease. Parametric and nonparametric linkage analysis did not provide evidence for linkage between KCNN3 (that we mapped to chromosome 1q21) and schizophrenia. Furthermore, we observed no difference in the distribution of the (CAG)n alleles between affected and normal individuals. These results do not support the hypothesis that larger KCNN3 alleles are preferentially associated with schizophrenia [Chandy et al. 1998 Mol Psychiatr 3:3237] in individuals from multiply affected families.

Original languageEnglish (US)
Pages (from-to)348-351
Number of pages4
JournalAmerican Journal of Medical Genetics - Neuropsychiatric Genetics
Volume88
Issue number4
DOIs
StatePublished - Aug 20 1999

Keywords

  • Chromosome I
  • Linkage analysis
  • Schizophrenia
  • Trinucleotide repeats

ASJC Scopus subject areas

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

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