Lack of IRS-1 codon 513 and 972 polymorphism in Pima Indians

Francesco S. Celi, Kristi Silver, Jeremy Walston, William C. Knowler, Clifton Bogardus, Alan R. Shuldiner

Research output: Contribution to journalArticle

Abstract

Insulin receptor substrate-1 (IRS-1), an endogenous substrate for the insulin receptor tyrosine kinase, mediates many or all of the metabolic actions of insulin. Recently, polymorphism at codons 513 and 972 of the IRS-1 gene resulting in 2 amino acid substitutions that were associated with type II diabetes were found in a Caucasian population. Using allele specific oligonucleotide (ASO) hybridization, we screened 242 diabetic and 190 nondiabetic Pima Indians, a population with a very high prevalence of type II diabetes. Neither of the two mutations was present in either diabetic or nondiabetic subjects. We conclude that polymorphism at codons 513 and 972 of the IRS-1 gene observed in certain Caucasian populations is very rare or absent in Pima Indians.

Original languageEnglish (US)
Pages (from-to)2827-2829
Number of pages3
JournalJournal of Clinical Endocrinology and Metabolism
Volume80
Issue number9
DOIs
StatePublished - Oct 1995

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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