Lack of increase in cell transformation frequency of C3H cells after exposure to pulsed ultrasound

W. H. Zhu, M. W. Miller, C. Cox

Research output: Contribution to journalArticle

Abstract

Libeskind et al.1 1 Liebeskind, D., Bases, R., Elequin, F., Neubort, S., Leifer, R., Goldberg, R. and Koenigsberg, M. Diagnostic ultrasound: effects on the DNA and growth patterns of animal cells Radiology (1979) 131 177-184 reported that ultrasound from a diagnostic ultrasound unit caused an increase in cell transformation of in vitro C3H cells. The objective of this study was to attempt verification of this result, using the same cell line and a similar ultrasound exposure regimen. Four experiments were undertaken, each involving an ultrasound, X-ray (positive control) and sham exposure regimen. There was no increase in cell transformation frequency with the ultrasound exposure, but a small and statistically significant increase with the X-ray regimen.

Original languageEnglish (US)
Pages (from-to)81-84
Number of pages4
JournalUltrasonics
Volume29
Issue number1
DOIs
StatePublished - Jan 1991
Externally publishedYes

Keywords

  • cell transformation
  • in vitro ultrasound
  • plating efficiency

ASJC Scopus subject areas

  • Acoustics and Ultrasonics

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