Lack of herpes virus DNA in choroidal tissues of a patient with serpiginous choroiditis

Esen K Akpek, Chi Chao Chan, Defen Shen, W. Richard Green

Research output: Contribution to journalArticle

Abstract

Objective To investigate the role of herpes viruses in the etiology of serpiginous choroiditis. Design Interventional case report. Participant A 59-year-old male patient with long-term history of serpiginous choroiditis. Intervention The patient's affected eye was obtained during autopsy. Polymerase chain reaction was performed in the microdissected choroidal tissues. Results Histopathologic examination demonstrated active inflammation with lymphocytic infiltration of the choroid. No viral DNA was amplified using pairs of herpes simplex virus (HSV) P1/P2 (for HSV-1, HSV-2, Epstein-Barr virus [EBV], cytomegalovirus [CMV] and human herpes virus [HHV]-8), and varicella-zoster virus [VZV] P1/P2 (for VZV, HHV-6, HHV-7) in the infiltrating lymphocytes or choroidal tissues. Conclusions The current observation suggests a lack of a role for herpetic viral etiology in the etiopathogenesis of serpiginous choroiditis.

Original languageEnglish (US)
Pages (from-to)2071-2075
Number of pages5
JournalOphthalmology
Volume111
Issue number11
DOIs
StatePublished - Nov 2004

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Choroiditis
DNA Viruses
Viruses
Human Herpesvirus 3
Human Herpesvirus 2
Choroid
Viral DNA
Human Herpesvirus 1
Simplexvirus
Cytomegalovirus
Human Herpesvirus 4
Autopsy
Observation
Lymphocytes
Inflammation
Polymerase Chain Reaction

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Lack of herpes virus DNA in choroidal tissues of a patient with serpiginous choroiditis. / Akpek, Esen K; Chan, Chi Chao; Shen, Defen; Green, W. Richard.

In: Ophthalmology, Vol. 111, No. 11, 11.2004, p. 2071-2075.

Research output: Contribution to journalArticle

Akpek, Esen K ; Chan, Chi Chao ; Shen, Defen ; Green, W. Richard. / Lack of herpes virus DNA in choroidal tissues of a patient with serpiginous choroiditis. In: Ophthalmology. 2004 ; Vol. 111, No. 11. pp. 2071-2075.
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