Lack of familial clustering of hepatitis C virus infection

Young Sik Kim, Hyun Sook Chi, Yoon Ok Ahn, Hyo Suk Lee, Michael John Klag

Research output: Contribution to journalArticle

Abstract

Background. Although transmission of hepatitis C virus (HCV) through parental exposure is well documented, it is still controversial whether familial clustering of HCV occurs. Methods. To investigate risk factors for HCV infection, 109 cases and 84 non-infected controls were studied. In addition, 250 family members (104 men, 146 women) of cases and 170 family members of controls (64 men, 106 women) were tested for HCV infection using an anti-HCV antibody, alanine aminotransferase (ALT), and reverse transcribed polymerase chain reaction (RT-PCR). Results. In the case-control analysis, people aged ≤ 60 were almost three times more likely to be infected by HCV than those aged <40. Risk of HCV infection was most strongly related to a history of blood transfusion (OR = 12.6, 95% CI: 4.3-36.5) followed by a history of jaundice (OR = 4.1, 95% CI: 1.3-12.6). Only one family member of cases and no-one related to the controls had HCV infection. Conclusions. These results suggest that, in Korea, age and parenteral exposure, such as a blood transfusion, are risk factors for HCV infection and familial clustering of HCV infection, if it occurs, is rare.

Original languageEnglish (US)
Pages (from-to)525-529
Number of pages5
JournalInternational Journal of Epidemiology
Volume27
Issue number3
DOIs
StatePublished - Jun 1998

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Virus Diseases
Hepacivirus
Cluster Analysis
Blood Transfusion
Hepatitis C Antibodies
Korea
Jaundice
Alanine Transaminase
Polymerase Chain Reaction

Keywords

  • Familial clustering
  • Hepatitis C virus
  • Reverse transcribed polymerase chain reaction
  • Risk factor

ASJC Scopus subject areas

  • Epidemiology

Cite this

Lack of familial clustering of hepatitis C virus infection. / Kim, Young Sik; Chi, Hyun Sook; Ahn, Yoon Ok; Lee, Hyo Suk; Klag, Michael John.

In: International Journal of Epidemiology, Vol. 27, No. 3, 06.1998, p. 525-529.

Research output: Contribution to journalArticle

Kim, Young Sik ; Chi, Hyun Sook ; Ahn, Yoon Ok ; Lee, Hyo Suk ; Klag, Michael John. / Lack of familial clustering of hepatitis C virus infection. In: International Journal of Epidemiology. 1998 ; Vol. 27, No. 3. pp. 525-529.
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