TY - JOUR
T1 - Lack of evidence for increased genetic loading for autism among families of affected females
T2 - A replication from family history data in two large samples
AU - Goin-Kochel, Robin P.
AU - Abbacchi, Anna
AU - Constantino, John N.
AU - Geschwind, Daniel H.
AU - Brown, W. Ted
AU - Bucan, Maya
AU - Buxbaum, Joseph
AU - Gilliam, T. Conrad
AU - Greenberg, David A.
AU - Ledbetter, David H.
AU - Miller, Bruce
AU - Nelson, Stanley F.
AU - Pevsner, Jonathan
AU - Schellenberg, Gerard D.
AU - Smango-Sprouse, Carol A.
AU - Tanzi, Rudolph E.
AU - Silverman, Jeremy M.
PY - 2007/5
Y1 - 2007/5
N2 - Both the broad and narrow phenotypes of autism have been consistently observed in family members of affected individuals. Additionally, autism spectrum disorders (ASDs) present four times more often in males than in females, for reasons that are currently unknown. In this study, we examined whether there were differences in familial loading of ASD among families of male versus female probands. Analyses were conducted with existing data from two distinct samples. The first sample contained 417 individuals with autism and Asperger's disorder and included information on the ASD diagnoses of their first- and second-degree relatives. The second sample consisted of 405 sibships participating in the Autism Genetic Resource Exchange, of which one or more siblings had an ASD diagnosis. Results from both samples did not suggest significant differences in the prevalence of ASD among relatives of affected males versus females.
AB - Both the broad and narrow phenotypes of autism have been consistently observed in family members of affected individuals. Additionally, autism spectrum disorders (ASDs) present four times more often in males than in females, for reasons that are currently unknown. In this study, we examined whether there were differences in familial loading of ASD among families of male versus female probands. Analyses were conducted with existing data from two distinct samples. The first sample contained 417 individuals with autism and Asperger's disorder and included information on the ASD diagnoses of their first- and second-degree relatives. The second sample consisted of 405 sibships participating in the Autism Genetic Resource Exchange, of which one or more siblings had an ASD diagnosis. Results from both samples did not suggest significant differences in the prevalence of ASD among relatives of affected males versus females.
KW - Asperger's disorder
KW - Autism
KW - Family history
KW - Genetics
UR - http://www.scopus.com/inward/record.url?scp=34249657900&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34249657900&partnerID=8YFLogxK
U2 - 10.1177/1362361307076857
DO - 10.1177/1362361307076857
M3 - Article
C2 - 17478580
AN - SCOPUS:34249657900
SN - 1362-3613
VL - 11
SP - 279
EP - 286
JO - Autism
JF - Autism
IS - 3
ER -