TY - JOUR
T1 - Lack of effect of ovarian denervation on ovulation and pregnancy in the rabbit
AU - Weiner, S.
AU - Wright, K. H.
AU - Wallach, E. E.
N1 - Funding Information:
Received April 7, 1975. *Supported by Population Council Grants M73.103 and M74.77 and National Institutes of Health Grant R01 HD-05948. tPresented at the Thirty-First Annual Meeting of The American Fertility Society, April 3 to 5, 1975, Los Angeles, Calif. :j:Reprint requests: Stuart Weiner, M.D., Department of Obstetrics and Gynecology, Pennsylvania Hospital, Eighth and Spruce Streets, Philadelphia, Pa. 19107.
PY - 1975
Y1 - 1975
N2 - Following unilateral ovarian denervation by ovarian artery stripping in female rabbits, ovulation and pregnancy were achieved within 3 days of denervation. Three weeks later, at repeat laparotomy, ovarian dimensions and the numbers of corpora lutea and pregnancies were noted. Fluorescent histochemical studies confirmed complete adrenergic denervation in five of the rabbits' ovaries. There was no significant difference in ovarian dimensions, numbers of corpora lutea and pregnancies, or the excess of corpora lutea over implantations when the intact control side was compared with the denervated side. The control ovaries demonstrated an average of 5 corpora lutea/ovary and an average of 3.4 conceptuses in the adjacent uterine horn, while the numbers on the denervated side were 5 and 3.2, respectively. Although these findings demonstrate that central neural efferent control is not essential for the occurrence of pregnancy after mating in the rabbit, the potential significance of ovarian neuromuscular mechanisms in these functions is discussed, and future studies are suggested.
AB - Following unilateral ovarian denervation by ovarian artery stripping in female rabbits, ovulation and pregnancy were achieved within 3 days of denervation. Three weeks later, at repeat laparotomy, ovarian dimensions and the numbers of corpora lutea and pregnancies were noted. Fluorescent histochemical studies confirmed complete adrenergic denervation in five of the rabbits' ovaries. There was no significant difference in ovarian dimensions, numbers of corpora lutea and pregnancies, or the excess of corpora lutea over implantations when the intact control side was compared with the denervated side. The control ovaries demonstrated an average of 5 corpora lutea/ovary and an average of 3.4 conceptuses in the adjacent uterine horn, while the numbers on the denervated side were 5 and 3.2, respectively. Although these findings demonstrate that central neural efferent control is not essential for the occurrence of pregnancy after mating in the rabbit, the potential significance of ovarian neuromuscular mechanisms in these functions is discussed, and future studies are suggested.
UR - http://www.scopus.com/inward/record.url?scp=0016725304&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0016725304&partnerID=8YFLogxK
U2 - 10.1016/S0015-0282(16)41474-3
DO - 10.1016/S0015-0282(16)41474-3
M3 - Article
C2 - 1183633
AN - SCOPUS:0016725304
SN - 0015-0282
VL - 26
SP - 1083
EP - 1087
JO - Fertility and sterility
JF - Fertility and sterility
IS - 11
ER -