TY - JOUR
T1 - Lack of Effect of Histamine H2‐Receptor Antagonists on Indocyanine Green Disposition Measured by Two Methods
AU - DONN, KARL H.
AU - POWELL, J. ROBERT
AU - ROGERS, JOHN F.
AU - PLACHETKA, JOHN R.
PY - 1984
Y1 - 1984
N2 - Abstract: Eleven healthy male volunteers were treated according to a randomized, crossover design with ranitidine (300 mg/day), cimetidine (1200 mg/day), or nothing for 48 hours. Ninety minutes after the 48‐hour dose, each volunteer was given 0.5 mg/kg indocyanine green by iv bolus. Indocyanine green plasma concentrations were measured by the traditional spectrophotometric method at 800 nm and by HPLC simultaneously monitored at 214 and 656 nm. Neither histamine H2‐receptor antagonist altered the disposition of indocyanine green. The mean (± S.D.) plasma clearance by the spectrophotometric method was 7.48 ± 2.07 (control), 7.15 ± 3.07 (ranitidine), and 6.88 ± 1.35 ml/min/kg (cimetidine). The power to detect a 20 per cent change is 0.87. The spectrophotometric method generally produced a biexponential plasma concentration decay, whereas the HPLC method resulted in a monoexponential decay. Analysis of the 5‐ to 15‐minute data by the conventional technique showed that although indocyanine green total plasma clearance was not significantly different for the two methods (P > 0.10), the volume of distribution was significantly greater (P < 0.001) and the elimination rate constant was significantly smaller (P < 0.001) for the spectrophotometric than the HPLC method. Although neither ranitidine nor cimetidine chronic administration alters indocyanine green disposition by either method, the absolute values of the pharmacokinetic parameters are dependent upon the analytical technique employed. 1984 American College of Clinical Pharmacology
AB - Abstract: Eleven healthy male volunteers were treated according to a randomized, crossover design with ranitidine (300 mg/day), cimetidine (1200 mg/day), or nothing for 48 hours. Ninety minutes after the 48‐hour dose, each volunteer was given 0.5 mg/kg indocyanine green by iv bolus. Indocyanine green plasma concentrations were measured by the traditional spectrophotometric method at 800 nm and by HPLC simultaneously monitored at 214 and 656 nm. Neither histamine H2‐receptor antagonist altered the disposition of indocyanine green. The mean (± S.D.) plasma clearance by the spectrophotometric method was 7.48 ± 2.07 (control), 7.15 ± 3.07 (ranitidine), and 6.88 ± 1.35 ml/min/kg (cimetidine). The power to detect a 20 per cent change is 0.87. The spectrophotometric method generally produced a biexponential plasma concentration decay, whereas the HPLC method resulted in a monoexponential decay. Analysis of the 5‐ to 15‐minute data by the conventional technique showed that although indocyanine green total plasma clearance was not significantly different for the two methods (P > 0.10), the volume of distribution was significantly greater (P < 0.001) and the elimination rate constant was significantly smaller (P < 0.001) for the spectrophotometric than the HPLC method. Although neither ranitidine nor cimetidine chronic administration alters indocyanine green disposition by either method, the absolute values of the pharmacokinetic parameters are dependent upon the analytical technique employed. 1984 American College of Clinical Pharmacology
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U2 - 10.1002/j.1552-4604.1984.tb02788.x
DO - 10.1002/j.1552-4604.1984.tb02788.x
M3 - Article
C2 - 6148361
AN - SCOPUS:0021222241
VL - 24
SP - 360
EP - 370
JO - Journal of Clinical Pharmacology
JF - Journal of Clinical Pharmacology
SN - 0091-2700
IS - 8-9
ER -